Literature summary for 4.1.2.25 extracted from

Hennig, M.; D'Arcy, A.; Hampele, I.C.; Page, M.G.P.; Oefner, C.; Dale, G.E.
Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus (1998), Nat. Struct. Biol., 5, 357-362.

Search for more literature for 4.1.2.25

Cloned(Commentary)

Cloned (Comment)	Organism
-	Staphylococcus aureus

Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Staphylococcus aureus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
13751	-	8 * 13751, calculation from nucleotide sequence	Staphylococcus aureus
110000	-	sedimentation equilibrium centrifugation	Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine	Staphylococcus aureus	the enzyme is involved in the de novo synthesis of folic acid from guanosine triphosphate	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Staphylococcus aureus

Reaction

Reaction	Comment	Organism	Reaction ID
7,8-dihydroneopterin = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde	mechanism	Staphylococcus aureus	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine	-	Staphylococcus aureus	2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde	-	?
2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine	the enzyme is involved in the de novo synthesis of folic acid from guanosine triphosphate	Staphylococcus aureus	?	-	?

Subunits

Subunits	Comment	Organism
More	four molecules assemble into a ring, and two rings come together to give a cylinder with a hole of at least 13 A diameter	Staphylococcus aureus
octamer	8 * 13751, calculation from nucleotide sequence	Staphylococcus aureus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)