Literature summary for 4.1.2.24 extracted from

  • Machinist, J.M.; Orme-Johnson, W.H.; Ziegler, D.M.
    Microsomal oxidases. II. Properties of a pork liver microsomal N-oxide dealkylase (1966), Biochemistry, 5, 2939-2943.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alpha-Phenyl-alpha-propyl-benzeneacetic acid 2-(diethylamino) ethyl ester SKF-525A Sus scrofa
CO
-
Sus scrofa
Pyridine
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7
-
N,N-dimethylnaphthylamine N-oxide in presence of N,N-dimethylcyclohexylamine Sus scrofa
20
-
N,N-Dimethyl-p-toluidine N-oxide in presence of N,N-dimethylcyclohexylamine Sus scrofa
80
-
N,N-Dimethylaniline N-oxide in presence of N,N-dimethylcyclohexylamine Sus scrofa
6
-
N,N-dimethylnaphthylamine N-oxide
-
Sus scrofa
15
-
N,N-Dimethyl-p-toluidine N-oxide
-
Sus scrofa
33
-
N,N-Dimethylaniline N-oxide
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Sus scrofa
-
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with N-oxide derivatives of trialkylamines, morphine N-ethyl derivatives of aniline N-oxide are dealkylated at a slower rate than methyl derivatives Sus scrofa ?
-
?
N,N-Dimethyl1-naphthylamine N-oxide
-
Sus scrofa N-Methylaniline + formaldehyde
-
?
N,N-Dimethyl-p-toluidine N-oxide
-
Sus scrofa ?
-
?
p-Chlorodimethylaniline N-oxide
-
Sus scrofa ?
-
?
N,N-Dimethylaniline N-oxide
-
Sus scrofa ?
-
?
N-Ethyl-N-methylaniline N-oxide weak activity Sus scrofa ?
-
?

Synonyms

Synonyms Comment Organism
Microsomal oxidase II
-
Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8 7
-
Sus scrofa