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Literature summary for 4.1.2.22 extracted from

  • Glenn, K.; Ingram-Smith, C.; Smith, K.S.
    Biochemical and kinetic characterization of xylulose 5-phosphate/fructose 6-phosphate phosphoketolase 2 (Xfp2) from Cryptococcus neoformans (2014), Eukaryot. Cell, 13, 657-663.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.2.22

Activating Compound

Activating Compound Comment Organism Structure
AMP acts as a very potent activator, 20 microM AMP is capable of increasing Xfp2 activity by 24.8%, while 50 microM prevent inhibition caused by 0.6 mM ATP. AMP and phosphoenolpyruvate/oxaloacetic acid operate independently, with AMP activating Xfp2 and phosphoenolpyruvate/oxaloacetic acid inhibiting the activated enzyme Cryptococcus neoformans

Inhibitors

Inhibitors Comment Organism Structure
ATP phosphoenolpyruvate and oxaloacetic acid share the same or have overlapping allosteric binding sites, while ATP binds at a separate site Cryptococcus neoformans
oxaloacetic acid phosphoenolpyruvate and oxaloacetic acid share the same or have overlapping allosteric binding sites, while ATP binds at a separate site. AMP and phosphoenolpyruvate/oxaloacetic acid operate independently, with AMP activating Xfp2 and phosphoenolpyruvate/oxaloacetic acid inhibiting the activated enzyme Cryptococcus neoformans
phosphoenolpyruvate phosphoenolpyruvate and oxaloacetic acid share the same or have overlapping allosteric binding sites, while ATP binds at a separate site. AMP and phosphoenolpyruvate/oxaloacetic acid operate independently, with AMP activating Xfp2 and phosphoenolpyruvate/oxaloacetic acid inhibiting the activated enzyme Cryptococcus neoformans

Organism

Organism UniProt Comment Textmining
Cryptococcus neoformans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information existence of both substrate cooperativity for all three substrates and allosteric regulation through the binding of effector molecules at sites separate from the active site Cryptococcus neoformans ?
-
 ?

Synonyms

Synonyms Comment Organism
Xf2
-
 Cryptococcus neoformans
xylulose 5-phosphate/fructose 6-phosphate phosphoketolase
-
 Cryptococcus neoformans

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.6
-
 pH not specified in the publication, temperature not specified in the publication Cryptococcus neoformans ATP