Literature summary for 4.1.2.13 extracted from

Zhang, C.S.; Hawley, S.A.; Zong, Y.; Li, M.; Wang, Z.; Gray, A.; Ma, T.; Cui, J.; Feng, J.W.; Zhu, M.; Wu, Y.Q.; Li, T.Y.; Ye, Z.; Lin, S.Y.; Yin, H.; Piao, H.L.; Hardie, D.G.; Lin, S.C.
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK (2017), Nature, 548, 112-116 .

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Protein Variants

Protein Variants	Comment	Organism
D34S	catalytically inactive mutant which still binds to D-fructose 1,6-bisphosphate	Homo sapiens
D34S	catalysis-defective mutant enzyme	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-fructose 1,6-bisphosphate	Homo sapiens	-	glycerone phosphate + D-glyceraldehyde 3-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-
HEK-293T cell	-	Homo sapiens	-
HEK-AD293 cell	-	Homo sapiens	-
liver	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-fructose 1,6-bisphosphate	-	Homo sapiens	glycerone phosphate + D-glyceraldehyde 3-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
aldoA	-	Homo sapiens
Fructose 1,6-bisphosphate aldolase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	knockdown of fructose-1,6-bisphosphate aldolases activates AMP-activated protein kinase even in cells with abundant glucose, while the catalysis-defective D34S aldolase mutant, which still binds fructose-1,6-bisphosphate, blocks AMP-activated protein kinase activation	Mus musculus
metabolism	the enzyme is a sensor of glucose availability that regulates AMP-activated protein kinase	Homo sapiens
physiological function	the enzyme is involved in glycolysis	Mus musculus
physiological function	the enzyme is a natural fructose-1,6-bisphosphate receptor that transmits the effects of glucose shortage to AMP-activated protein kinase via the v-ATPase-Ragulator-AXIN/LKB1 complex	Mus musculus

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Release 2023.1 (January 2023)