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Literature summary for 4.1.2.13 extracted from

  • Fonvielle, M.; Coincon, M.; Daher, R.; Desbenoit, N.; Kosieradzka, K.; Barilone, N.; Gicquel, B.; Sygusch, J.; Jackson, M.; Therisod, M.
    Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics (2008), Chemistry, 14, 8521-8529.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Helicobacter pylori

Inhibitors

Inhibitors Comment Organism Structure
N-(3-hydroxypropyl)-glycolohydrazide-bisphosphate fructose-1,6-bisphosphate analogue Helicobacter pylori
N-(3-hydroxypropyl)-glycolohydrazide-bisphosphate fructose-1,6-bisphosphate analogue Mycobacterium tuberculosis
N-(3-hydroxypropyl)-glycolohydrazide-bisphosphate fructose-1,6-bisphosphate analogue Oryctolagus cuniculus
N-(3-hydroxypropyl)-glycolohydrazide-bisphosphate fructose-1,6-bisphosphate analogue Saccharomyces cerevisiae
N-(3-hydroxypropyl)-glycolohydroxamic acid bisphosphate fructose-1,6-bisphosphate analogue, best results Helicobacter pylori
N-(3-hydroxypropyl)-glycolohydroxamic acid bisphosphate fructose-1,6-bisphosphate analogue, weakly active Mycobacterium tuberculosis
N-(3-hydroxypropyl)-glycolohydroxamic acid bisphosphate fructose-1,6-bisphosphate analogue, best results Oryctolagus cuniculus
N-(3-hydroxypropyl)-glycolohydroxamic acid bisphosphate fructose-1,6-bisphosphate analogue, best results Saccharomyces cerevisiae
N-(3-hydroxypropyl)-phosphoglycolohydroxamic acid fructose-1,6-bisphosphate analogue Helicobacter pylori
N-(3-hydroxypropyl)-phosphoglycolohydroxamic acid fructose-1,6-bisphosphate analogue Mycobacterium tuberculosis
N-(3-hydroxypropyl)-phosphoglycolohydroxamic acid fructose-1,6-bisphosphate analogue Oryctolagus cuniculus
N-(3-hydroxypropyl)-phosphoglycolohydroxamic acid fructose-1,6-bisphosphate analogue Saccharomyces cerevisiae
phosphoglycoloamidoxime dihydroxyacetone phosphate analogue Helicobacter pylori
phosphoglycoloamidoxime dihydroxyacetone phosphate analogue Mycobacterium tuberculosis
phosphoglycoloamidoxime dihydroxyacetone phosphate analogue Oryctolagus cuniculus
phosphoglycoloamidoxime dihydroxyacetone phosphate analogue Saccharomyces cerevisiae
phosphoglycolohydrazide dihydroxyacetone phosphate analogue Helicobacter pylori
phosphoglycolohydrazide dihydroxyacetone phosphate analogue Mycobacterium tuberculosis
phosphoglycolohydrazide dihydroxyacetone phosphate analogue Oryctolagus cuniculus
phosphoglycolohydrazide dihydroxyacetone phosphate analogue Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
D-fructose-1,6-bisphosphate
-
Helicobacter pylori
0.055
-
D-fructose-1,6-bisphosphate
-
Oryctolagus cuniculus
0.45
-
D-fructose-1,6-bisphosphate
-
Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+
-
Mycobacterium tuberculosis
Co2+
-
Oryctolagus cuniculus
Co2+
-
Saccharomyces cerevisiae
Co2+
-
Helicobacter pylori
Zn2+
-
Mycobacterium tuberculosis
Zn2+
-
Oryctolagus cuniculus
Zn2+
-
Saccharomyces cerevisiae
Zn2+
-
Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-fructose-1,6-bisphosphate Mycobacterium tuberculosis
-
dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
r
D-fructose-1,6-bisphosphate Oryctolagus cuniculus
-
dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
r
D-fructose-1,6-bisphosphate Saccharomyces cerevisiae
-
dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
r
D-fructose-1,6-bisphosphate Helicobacter pylori
-
dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
r
D-fructose-1,6-bisphosphate Mycobacterium tuberculosis H37Rv
-
dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
r

Organism

Organism UniProt Comment Textmining
Helicobacter pylori P56109
-
-
Mycobacterium tuberculosis P9WQA3
-
-
Mycobacterium tuberculosis H37Rv P9WQA3
-
-
Oryctolagus cuniculus P00883
-
-
Saccharomyces cerevisiae P14540
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose-1,6-bisphosphate
-
Mycobacterium tuberculosis dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
r
D-fructose-1,6-bisphosphate
-
Oryctolagus cuniculus dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
r
D-fructose-1,6-bisphosphate
-
Saccharomyces cerevisiae dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
r
D-fructose-1,6-bisphosphate
-
Helicobacter pylori dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
r
D-fructose-1,6-bisphosphate
-
Mycobacterium tuberculosis H37Rv dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
-
r

Synonyms

Synonyms Comment Organism
class I fructose bisphosphate aldolase
-
Oryctolagus cuniculus
class II fructose bisphosphate aldolase
-
Mycobacterium tuberculosis
class II fructose bisphosphate aldolase
-
Saccharomyces cerevisiae
class II fructose bisphosphate aldolase
-
Helicobacter pylori
FBA
-
Mycobacterium tuberculosis
FBA
-
Oryctolagus cuniculus
FBA
-
Saccharomyces cerevisiae
FBA
-
Helicobacter pylori