Literature summary for 4.1.2.13 extracted from

Bais, R.; James, H.M.; Rofe, A.M.; Conyers, A.J.
The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol (1985), Biochem. J., 230, 53-60.

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Inhibitors

Inhibitors	Comment	Organism	Structure
ADP	-	Homo sapiens
ascorbic acid	-	Homo sapiens
ATP	-	Homo sapiens
erythrose 4-phosphate	-	Homo sapiens
fructose 6-phosphate	-	Homo sapiens
glucose 1-phosphate	-	Homo sapiens
glucose 6-phosphate	-	Homo sapiens
Glycerol 2,3-diphosphate	-	Homo sapiens
glyoxylate	-	Homo sapiens
IMP	-	Homo sapiens
ribose 5-phosphate	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0016	-	D-Xylulose 1-phosphate	-	Homo sapiens
0.0037	-	D-fructose 1,6-bisphosphate	-	Homo sapiens
2	-	fructose 1-phosphate	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partial	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
heart	-	Homo sapiens	-
kidney	-	Homo sapiens	-
liver	-	Homo sapiens	-
muscle	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-fructose 1,6-bisphosphate	-	Homo sapiens	glycerone phosphate + D-glyceraldehyde 3-phosphate	-	?
D-Fructose 1-phosphate	99% of the activity with fructose 1,6-diphosphate	Homo sapiens	Glycerone phosphate + D-glyceraldehyde	-	?
D-Xylulose 1-phosphate	110% of the activity with fructose 1,6-diphosphate	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)