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Literature summary for 4.1.2.11 extracted from
- Hydroxynitrile lyase-catalyzed synthesis of cyanohydrins in organic solvents. Parameters influencing activity and enantiospecificity (1999), Enzyme Microb. Technol., 25, 384-391.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | biocatalyst for the enantiospecific addition of hydrogen cyanide to aldehydes in organic solvents | Sorghum bicolor |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cyanide + 4-hydroxybenzaldehyde | Sorghum bicolor | - |
(S)-4-hydroxymandelonitrile | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sorghum bicolor | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cyanide + 4-hydroxybenzaldehyde | - |
Sorghum bicolor | (S)-4-hydroxymandelonitrile | - |
r | |
| HCN + 3-phenylpropionaldehyde | - |
Sorghum bicolor | 2-hydroxy-4-phenylbutanenitrile | - |
? | |
| HCN + 3-phenylpropionaldehyde | - |
Sorghum bicolor | (2S)-2-hydroxy-4-phenylbutanenitrile | 17% enantiomeric excess | ? | |
| HCN + 4-hydroxybenzaldehyde | - |
Sorghum bicolor | (S)-4-hydroxymandelonitrile | - |
? | |
| HCN + acrolein | - |
Sorghum bicolor | 2-hydroxybut-3-enenitrile | - |
? | |
| HCN + acrolein | - |
Sorghum bicolor | (2S)-2-hydroxybut-3-enenitrile | 25% enantiomeric excess | ? | |
| HCN + benzaldehyde | - |
Sorghum bicolor | (S)-mandelonitrile | - |
? | |
| HCN + benzaldehyde | - |
Sorghum bicolor | (S)-mandelonitrile | 99% enantiomeric excess | ? | |
| additional information | When the temperature decreases from 25°C to -5°C, the enantiomeric excess increases from 18% to 30% | Sorghum bicolor | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| (S)-Sb-HNL | - |
Sorghum bicolor |
| HNL | - |
Sorghum bicolor |
| Hydroxynitrile lyase | - |
Sorghum bicolor |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| -5 | 25 | when the temperature decreases from 25°C to -5°C, the enantiomeric excess increases from 18% to 30% | Sorghum bicolor |
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Release 2023.1 (January 2023)
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