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Literature summary for 4.1.2.11 extracted from

  • Lauble, H.; Miehlich, B.; Foerster, S.; Wajant, H.; Effenberger, F.
    Crystal structure of hydroxynitrile lyase from Sorghum bicolor in complex with the inhibitor benzoic acid: a novel cyanogenic enzyme (2002), Biochemistry, 41, 12043-12050.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme in complex with the inhibitor benzoic acid determined at 2.3 A resolution and refined to a crystallographic R-factor of 16.5%, space group C2, cell dimensions a = 150.7 A, b = 103.7 A, c = 90.6 A, beta = 101.3° Sorghum bicolor

Inhibitors

Inhibitors Comment Organism Structure
benzoic acid
-
 Sorghum bicolor

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-4-Hydroxymandelonitrile Sorghum bicolor
-
 Cyanide + 4-hydroxybenzaldehyde
-
 ?

Organism

Organism UniProt Comment Textmining
Sorghum bicolor P52708
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-4-Hydroxymandelonitrile
-
 Sorghum bicolor Cyanide + 4-hydroxybenzaldehyde
-
 ?
HCN + 4-hydroxybenzaldehyde (S)-specific Sorghum bicolor (S)-4-hydroxymandelonitrile
-
 ?
additional information substrate range of SbHNL is limited to aromatic and heteroaromatic aldehydes, does not accept aliphatic aldehydes as substrates Sorghum bicolor ?
-
 ?

Synonyms

Synonyms Comment Organism
HNL
-
 Sorghum bicolor
Hydroxynitrile lyase
-
 Sorghum bicolor
SbHNL
-
 Sorghum bicolor