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Literature summary for 4.1.1.98 extracted from

  • Leppik, R.; Young, I.; Gibson, F.
    Membrane associated reactions in ubiquinone biosynthesis in Escherichia coli. 3-Octaprenyl-4-hydroxybenzoate carboxy lyase (1976), Biochim. Biophys. Acta, 436, 800-810.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol slight stimulation of activity at 10 mM Escherichia coli
dithiothreitol maximal stimulation of activity at about 10 mM Escherichia coli
glutathione slight stimulation of activity at 10 mM Escherichia coli
lipoate slight (20%) stimulation of activity at 10 mM Escherichia coli
methanol strong stimulation Escherichia coli
additional information not activated by thiamine diphosphate, coenzyme A, pyridoxamine phosphate, pyridoxall 5'-phosphate, biotin, ascorbic acid, NADH, NADPH, folic acid, FAD, FMN, or glutamate Escherichia coli
Phospholipid
-
Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
EDTA complete inhibition at 1 mM Escherichia coli
Protamine sulfate treatment of cell extract with 90% of the volume of protamine sulfate solution needed to completely precipitate nucleic acids results in a loss of more than 95% of the total enzyme activity Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Escherichia coli 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ for optimal activity the enzyme requires Mn2+ Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
340000
-
gel filtration Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-octaprenyl-4-hydroxybenzoate
-
Escherichia coli 2-octaprenylphenol + CO2
-
?

Synonyms

Synonyms Comment Organism
3-octaprenyl-4-hydroxybenzoate carboxy-lyase
-
Escherichia coli