Cloned (Comment) | Organism |
---|---|
expression in Sf9 cell | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
FLEEL + CO2 + O2 + proFIX 19 | - |
Homo sapiens | ? + vitamin K epoxide + H2O | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | characterization of specific domains of GGCX that exhibit structural rearrangements upon binding the high-affinity consensus propeptide pCon (AVFLSREQANQVLQRRRR). pCon binding is specific for monomeric GGCX-nanodiscs and promotes enhanced structural stability to the nanodisc-integrated complex while maintaining catalytic activity in the presence of carboxylation cosubstrates. Modifications in hydrogen exchange of GGCX are prominently observed in GGCX peptides 491-507 and 395-401 upon pCon association, consistent with sites for propeptide and glutamate binding | Homo sapiens |