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Literature summary for 4.1.1.90 extracted from

  • Price, P.A.; Williamson, M.K.
    Substrate recognition by the vitamin K-dependent gamma-glutamyl carboxylase: Identification of a sequence homology between the carboxylase and the carboxylase recognition site in the substrate (1993), Protein Sci., 2, 1987-1988.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens vitamin K-dependent carboxylation of glutamate to form gamma-carboxyglutamate (Gla) is unusual among known posttranslational modifications in that substrate recognition does not require a specific sequence around the glutamate residues to be modified ?
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?
additional information Bos taurus vitamin K-dependent carboxylation of glutamate to form gamma-carboxyglutamate (Gla) is unusual among known posttranslational modifications in that substrate recognition does not require a specific sequence around the glutamate residues to be modified ?
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?

Organism

Organism UniProt Comment Textmining
Bos taurus Q07175
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-
Homo sapiens P38435
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate + CO2 + O2 + vitamin K hydroquinone
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Homo sapiens gamma-carboxy L-glutamate + vitamin K epoxide + H2O
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?
L-glutamate + CO2 + O2 + vitamin K hydroquinone
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Bos taurus gamma-carboxy L-glutamate + vitamin K epoxide + H2O
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?
additional information vitamin K-dependent carboxylation of glutamate to form gamma-carboxyglutamate (Gla) is unusual among known posttranslational modifications in that substrate recognition does not require a specific sequence around the glutamate residues to be modified Homo sapiens ?
-
?
additional information vitamin K-dependent carboxylation of glutamate to form gamma-carboxyglutamate (Gla) is unusual among known posttranslational modifications in that substrate recognition does not require a specific sequence around the glutamate residues to be modified Bos taurus ?
-
?
additional information identification of a striking homology between exon 3 in all known matrix Gla proteins and a 24-residue sequence in the bovine and human gamma-glutamyl carboxylases. Alignment of exon 3 of matrix Gla protein with the homologous region of the gamma-glutamyl carboxylase shown Homo sapiens ?
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?
additional information identification of a striking homology between exon 3 in all known matrix Gla proteins and a 24-residue sequence in the bovine and human gamma-glutamyl carboxylases. Alignment of exon 3 of matrix Gla protein with the homologous region of the gamma-glutamyl carboxylase shown Bos taurus ?
-
?

Synonyms

Synonyms Comment Organism
gamma-glutamyl carboxylase
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Homo sapiens
gamma-glutamyl carboxylase
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Bos taurus
glutamate carboxylase
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Homo sapiens
glutamate carboxylase
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Bos taurus
matrix gamma-carboxyglutamate protein
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Homo sapiens
matrix gamma-carboxyglutamate protein
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Bos taurus
matrix Gla protein
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Homo sapiens
matrix Gla protein
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Bos taurus

Cofactor

Cofactor Comment Organism Structure
vitamin K
-
Homo sapiens
vitamin K
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Bos taurus