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Literature summary for 4.1.1.90 extracted from

  • Stafford, D.W.
    The vitamin K cycle (2005), J. Thromb. Haemost., 3, 1873-1878.
    View publication on PubMed
Search for more literature for 4.1.1.90

Application

Application Comment Organism
medicine warfarin therapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
L128R warfarin resistent mutant Homo sapiens
R58G warfarin resistent mutant Homo sapiens
V29L warfarin resistent mutant Homo sapiens
V45A warfarin resistent mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the carboxylase reaction is inhibited by sulfhydryl-specific reagents Homo sapiens
warfarin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens vitamin K-dependent proteins require carboxylation for activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate + CO2 + O2 + vitamin K hydroquinone
-
 Homo sapiens gamma-carboxy-L-glutamate + vitamin K epoxide + H2O
-
 ?
additional information vitamin K-dependent proteins require carboxylation for activity Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More disulfide bond between cysteines 99 and 450, five transmembrane domains Homo sapiens

Synonyms

Synonyms Comment Organism
gamma glutamyl carboxylase
-
 Homo sapiens
GGCX
-
 Homo sapiens
glutamate carboxylase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
vitamin K
-
 Homo sapiens