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Literature summary for 4.1.1.90 extracted from
- Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status (2009), J. Nutr. Sci. Vitaminol., 55, 112-119.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gamma-glutamyl carboxylase | - |
Homo sapiens |
| GGCX | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | genetic variation in GGCX influences the gamma carboxylation of vitamin K-dependent proteins, as measured by differences in percent undercarboxylated osteocalcin and proteins induced by vitamin K absence-factor II (PIVKA-II). Heterozygous carriers of GGCX rs10187424 and rs7568458 have significantly lower percent undercarboxylated osteocalcin relative to either homozygous group. No significant differences within GGCX genotype group for plasma phylloquinone. No significant associations of GGCX polymorphisms and PIVKA-II | Homo sapiens |
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Release 2023.1 (January 2023)
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