Literature summary for 4.1.1.90 extracted from

Maillet, M.; Morris, D.; Gaudry, M.; Marquet, A.
The active site region of the vitamin K-dependent carboxylase includes both the amino-terminal hydrophobic and carboxy-terminal hydrophilic domains of the protein (1997), FEBS Lett., 413, 1-6.

Search for more literature for 4.1.1.90

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	15 min irradiation in the absence of peptide resulted in a 10% inactivation of the carboxylase	Bos taurus
proFIX/PT28 (Bpa +4)	presence of proFIX/PT28 (Bpa +4) or its iodinated derivative 56% inactivation is observed	Bos taurus
TVFLDHENANKILNRPKRANTBLEEVRK	the enzyme is photoirradiated on ice at 365 nm with TVFLDHENANKILNRPKRANTBLEEVRK, TVFLDHENANKILNRPKRYNTBLEEVRK and mono [127I]TVFLDHENANKILNRPKRYNTBLEEVRK for various times	Bos taurus
TVFLDHENANKILNRPKRYNTBLEEVRK	the enzyme is photoirradiated on ice at 365 nm with TVFLDHENANKILNRPKRANTBLEEVRK, TVFLDHENANKILNRPKRYNTBLEEVRK and mono [127I]TVFLDHENANKILNRPKRYNTBLEEVRK for various times. Presence of TVFLDHENANKILNRPKRYNTBLEEVRK or its iodinated derivative 80% inactivation is observed	Bos taurus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0068	-	TVFLDHENANKILNRPKRANTBLEEVRK	carboxylase probe1, TVFLDHENANKILNRPKRANTBLEEVRK as a substrate	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	Q07175	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
FLEEV + CO2 + O2 + vitamin K hydroquinone	-	Bos taurus	? + vitamin K epoxide + H2O	-	?
additional information	photolabeling of Q-glutamyl carboxylase with Bpa peptides	Bos taurus	?	-	?
proFIX 19 + CO2 + O2 + vitamin K hydroquinone	proFIX 19, peptide sequence: TVFLDHENANKILNRPKRY	Bos taurus	? + vitamin K epoxide + H2O	-	?
proFIX/PT28 + CO2 + O2 + vitamin K hydroquinone	proFIX/PT28, peptide sequence: TVFLDHENANKILNRPKRANTFLEEVRK	Bos taurus	? + vitamin K epoxide + H2O	-	?
TVFLDHENANKILNRPKRANTBLEEVRK + CO2 + O2 + vitamin K hydroquinone	carboxylase probe1, TVFLDHENANKILNRPKRANTBLEEVRK as a substrate	Bos taurus	? + vitamin K epoxide + H2O	-	?
TVFLDHENANKILNRPKRYNTBLEEVRK + CO2 + O2 + vitamin K hydroquinone	-	Bos taurus	? + vitamin K epoxide + H2O	-	?

Subunits

Subunits	Comment	Organism
More	limited tryptic digestion of the carboxylase yields two disulfide-linked fragments with molecular masses of 30 and 60 kDa, corresponding to the amino and carboxy-terminal part of the gamma-glutamyl carboxylase	Bos taurus

Synonyms

Synonyms	Comment	Organism
gamma-glutamyl carboxylase	-	Bos taurus
glutamate carboxylase	-	Bos taurus

Cofactor

Cofactor	Comment	Organism	Structure
vitamin K	-	Bos taurus

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Release 2023.1 (January 2023)