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Literature summary for 4.1.1.90 extracted from

  • Berkner, K.L.
    The vitamin K-dependent carboxylase (2005), Annu. Rev. Nutr., 25, 127-149.
    View publication on PubMed
Search for more literature for 4.1.1.90

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum potential impact of quality control components on carboxylation, which occurs in the endoplasmic reticulum during the secretion of vitamin KĀ–dependent proteins Homo sapiens 5783
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens uses the oxygenation of vitamin K to convert glutamyl residues to gamma-carboxylated glutamyl residues in vitamin KĀ–dependent proteins ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gamma-carboxylated glutamyl containing vitamin K-dependent protein + vitamin K epoxide + H2O
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 Homo sapiens ?
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 ?
glutamyl containing vitamin K-dependent protein + CO2 + vitamin K hydroquinone + O2 propeptide binding increases carboxylase affinity for the Glu substrate, and the coordinated binding of the vitamin KĀ–dependent propeptide and Glu substrate increase carboxylase affinity for vitamin K and activity, possibly through a mechanism of substrate-assisted catalysis. The propeptide adjacent to the Gla domain is cleaved subsequently to carboxylation. The carboxylase uses the energy of vitamin K hydroquinone oxygenation to convert glutamyl residues to gamma-carboxylated glutamyl residues in vitamin KĀ–dependent proteins. During carboxylation, the vitamin K hydroquinone cofactor is oxidized to a vitamin K epoxide product. The carboxylase itself is also a vitamin KĀ–dependent protein and carboxylase carboxylation may be important in regulating the overall process of vitamin KĀ–dependent protein carboxylation. All vitamin KĀ–dependent proteins contain multiple glutamyl residues that undergo carboxylation, which is accomplished by a processive mechanism. A single binding event between carboxylase and vitamin KĀ–dependent protein can give rise to all of the glutamyl to gamm-carboxylated glutamyl conversions in the vitamin KĀ–dependent protein. Carboxylation is limited to the glutamyl residue residing within the Gla domain Homo sapiens ?
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 ?
additional information uses the oxygenation of vitamin K to convert glutamyl residues to gamma-carboxylated glutamyl residues in vitamin KĀ–dependent proteins Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
glutamate carboxylase
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 Homo sapiens
VKD carboxylase
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 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
vitamin K the carboxylase uses the energy of vitamin K hydroquinone oxygenation to convert glutamyl residues to gamma-carboxylated glutamyl residues in vitamin KĀ–dependent proteins. During carboxylation, the vitamin K hydroquinone cofactor is oxidized to a vitamin K epoxide product Homo sapiens