Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.9 extracted from

  • Ussher, J.R.; Fillmore, N.; Keung, W.; Zhang, L.; Mori, J.; Sidhu, V.K.; Fukushima, A.; Gopal, K.; Lopaschuk, D.G.; Wagg, C.S.; Jaswal, J.S.; Dyck, J.R.; Lopaschuk, G.D.
    Genetic and pharmacological inhibition of malonyl CoA decarboxylase does not exacerbate age-related insulin resistance in mice (2016), Diabetes, 65, 1883-1891 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CBM-3001106
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Malonyl-CoA Mus musculus
-
Acetyl-CoA + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q99J39
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Malonyl-CoA
-
Mus musculus Acetyl-CoA + CO2
-
?

Synonyms

Synonyms Comment Organism
malonyl CoA decarboxylase
-
Mus musculus
MCD
-
Mus musculus

General Information

General Information Comment Organism
malfunction decreased fat oxidation in enzyme-deficient mice results in the accumulation of lipid intermediates in peripheral tissues, but this is not associated with a worsening of age-associated insulin resistance and, conversely, improves longevity. This improvement is associated with reduced oxidative stress and reduced acetylation of the antioxidant enzyme superoxide dismutase 2 in muscle but not the liver Mus musculus