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Literature summary for 4.1.1.9 extracted from

  • Rodriguez, S.; Ellis, J.M.; Wolfgang, M.J.
    Chemical-genetic induction of malonyl-CoA decarboxylase in skeletal muscle (2014), BMC Biochem., 15, 20 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.9

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Malonyl-CoA Mus musculus
-
 Acetyl-CoA + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q99J39
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Malonyl-CoA
-
 Mus musculus Acetyl-CoA + CO2
-
 ?

Synonyms

Synonyms Comment Organism
MCD
-
 Mus musculus

General Information

General Information Comment Organism
physiological function a two week induction of the enzyme in skeletal muscle does not alter body weight or ameliorate glucose intolerance, conversely it further impairs insulin signaling in the skeletal muscle of diet-induced obese mice. Furthermore, an acute induction of the enzyme leads to a suppression of fatty acid oxidative genes suggesting a redundant and metabolite driven regulation of gene expression Mus musculus