Literature summary for 4.1.1.9 extracted from

Lo, M.C.; Wang, M.; Kim, K.W.; Busby, J.; Yamane, H.; Zondlo, J.; Yuan, C.; Young, S.W.; Xiao, S.H.
A highly sensitive high-throughput luminescence assay for malonyl-CoA decarboxylase (2008), Anal. Biochem., 376, 122-130.

Search for more literature for 4.1.1.9

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli strain BL21	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
L-malate	-	Homo sapiens
N-methyl-2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide	-	Homo sapiens
NAD+	-	Homo sapiens
tert-butyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0087	-	malonyl-CoA	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Talon metal affinity resin chromatography, SP Sepharose column chromatography	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Malonyl-CoA	-	Homo sapiens	Acetyl-CoA + CO2	-	ir

Synonyms

Synonyms	Comment	Organism
MCD	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
47.3	-	malonyl-CoA	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000009	-	in 40 mM Tris, pH 8.0	Homo sapiens	tert-butyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
0.000814	-	in 40 mM Tris, pH 8.0	Homo sapiens	N-methyl-2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide
2.2	-	in 40 mM Tris, pH 8.0	Homo sapiens	NAD+
4.1	-	in 40 mM Tris, pH 8.0	Homo sapiens	L-malate

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Release 2023.1 (January 2023)