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Literature summary for 4.1.1.9 extracted from

  • Wallace, D.M.; Haramura, M.; Cheng, J.F.; Arrhenius, T.; Nadzan, A.M.
    Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors (2007), Bioorg. Med. Chem. Lett., 17, 1127-1130.
    View publication on PubMed
Search for more literature for 4.1.1.9

Inhibitors

Inhibitors Comment Organism Structure
2,2,2-trifluoro-1-[4-(pyrrolidin-1-ylcarbonyl)phenyl]ethanone
-
 Rattus norvegicus
2-methyl-N-[4-(trifluoroacetyl)phenyl]propanamide
-
 Rattus norvegicus
2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
-
 Rattus norvegicus
3-(2-methylpropyl)-1-propyl-1-[4-(trifluoroacetyl)phenyl]urea
-
 Rattus norvegicus
3-nitrophenyl 3-[(2-methylpropyl)(phenylcarbonyl)amino]propaneperoxoyl-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
4-(trifluoroacetyl)-N-[3-(trifluoromethyl)phenyl]benzamide
-
 Rattus norvegicus
4-cyano-N-[4-(trifluoroacetyl)phenyl]benzamide
-
 Rattus norvegicus
N,N-bis(2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N,N-diethyl-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N,N-dipropyl-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(1,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(1-methylethyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(1-methylethyl)-N-phenyl-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(1-methylhexyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(2-cyanoethyl)-N-ethyl-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(2-cyanoethyl)-N-phenoxy-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(2-methylcyclohexyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(2-methylcyclopropyl)-N-propyl-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(3,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(3-phenoxypropyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(4-phenoxybutyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(cyclohexylmethyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-(furan-2-ylmethyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-ethyl-N-(2-hydroxy-2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-ethyl-N-(2-methoxyethyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-hexyl-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-methyl-2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
-
 Rattus norvegicus
N-methyl-N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-[(2-hydroxyphenoxy)methyl]-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-[3,5-bis(trifluoromethyl)phenyl]-4-(trifluoroacetyl)benzamide
-
 Rattus norvegicus
N-[4-(trifluoroacetyl)phenyl]morpholine-4-carboxamide
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Malonyl-CoA
-
 Rattus norvegicus Acetyl-CoA + CO2
-
 ?

Synonyms

Synonyms Comment Organism
MCD
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000068
-
-
 Rattus norvegicus N-(2-methylcyclopropyl)-N-propyl-4-(trifluoroacetyl)benzamide
0.000073
-
-
 Rattus norvegicus N,N-bis(2-methylpropyl)-4-(trifluoroacetyl)benzamide
0.00008
-
-
 Rattus norvegicus 3-nitrophenyl 3-[(2-methylpropyl)(phenylcarbonyl)amino]propaneperoxoyl-4-(trifluoroacetyl)benzamide
0.000115
-
-
 Rattus norvegicus N-(1-methylhexyl)-4-(trifluoroacetyl)benzamide
0.000153
-
-
 Rattus norvegicus N,N-dipropyl-4-(trifluoroacetyl)benzamide
0.000155
-
-
 Rattus norvegicus N-(2-cyanoethyl)-N-phenoxy-4-(trifluoroacetyl)benzamide
0.000214
-
-
 Rattus norvegicus N-(2-cyanoethyl)-N-ethyl-4-(trifluoroacetyl)benzamide
0.000242
-
-
 Rattus norvegicus N-(1,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
0.000304
-
-
 Rattus norvegicus N-(2-methylcyclohexyl)-4-(trifluoroacetyl)benzamide
0.000399
-
-
 Rattus norvegicus N-ethyl-N-(2-hydroxy-2-methylpropyl)-4-(trifluoroacetyl)benzamide
0.000507
-
-
 Rattus norvegicus 4-(trifluoroacetyl)-N-[3-(trifluoromethyl)phenyl]benzamide
0.000566
-
-
 Rattus norvegicus N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
0.000654
-
-
 Rattus norvegicus N-[3,5-bis(trifluoromethyl)phenyl]-4-(trifluoroacetyl)benzamide
0.000679
-
-
 Rattus norvegicus N-hexyl-4-(trifluoroacetyl)benzamide
0.000953
-
-
 Rattus norvegicus N-methyl-N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
0.001105
-
-
 Rattus norvegicus N-ethyl-N-(2-methoxyethyl)-4-(trifluoroacetyl)benzamide
0.001351
-
-
 Rattus norvegicus N-(3-phenoxypropyl)-4-(trifluoroacetyl)benzamide
0.0015
-
-
 Rattus norvegicus 2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
0.001531
-
-
 Rattus norvegicus N-(2-methylpropyl)-4-(trifluoroacetyl)benzamide
0.001619
-
-
 Rattus norvegicus N,N-diethyl-4-(trifluoroacetyl)benzamide
0.001731
-
-
 Rattus norvegicus N-(1-methylethyl)-N-phenyl-4-(trifluoroacetyl)benzamide
0.001739
-
-
 Rattus norvegicus N-(4-phenoxybutyl)-4-(trifluoroacetyl)benzamide
0.002034
-
-
 Rattus norvegicus N-(furan-2-ylmethyl)-4-(trifluoroacetyl)benzamide
0.002298
-
-
 Rattus norvegicus N-(cyclohexylmethyl)-4-(trifluoroacetyl)benzamide
0.002753
-
-
 Rattus norvegicus N-(3,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
0.0028
-
-
 Rattus norvegicus 3-(2-methylpropyl)-1-propyl-1-[4-(trifluoroacetyl)phenyl]urea
0.00328
-
-
 Rattus norvegicus 2,2,2-trifluoro-1-[4-(pyrrolidin-1-ylcarbonyl)phenyl]ethanone
0.003361
-
-
 Rattus norvegicus N-(1-methylethyl)-4-(trifluoroacetyl)benzamide
0.0045
-
-
 Rattus norvegicus N-methyl-2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
0.0049
-
-
 Rattus norvegicus 4-cyano-N-[4-(trifluoroacetyl)phenyl]benzamide
0.005011
-
-
 Rattus norvegicus N-[(2-hydroxyphenoxy)methyl]-4-(trifluoroacetyl)benzamide
0.00545
-
-
 Rattus norvegicus 2-methyl-N-[4-(trifluoroacetyl)phenyl]propanamide
0.0172
-
-
 Rattus norvegicus N-[4-(trifluoroacetyl)phenyl]morpholine-4-carboxamide