Literature summary for 4.1.1.9 extracted from

Young, M.E.; Goodwin, G.W.; Ying, J.; Guthrie, P.; Wilson, C.R.; Laws, F.A.; Taegtmeyer, H.
Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids (2001), Am. J. Physiol. Endocrinol. Metab., 280, E471-479.

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Activating Compound

Activating Compound	Comment	Organism	Structure
fatty acid	increases MCD expression in heart and skeletal muscle	Rattus norvegicus
additional information	high-fat feeding, fasting and streptozotocin-induced diabetes increase the plasma concentration of nonesterified fatty acids, with a concomitant increase in both heart and skeletal muscle MCD mRNA	Rattus norvegicus
WY-14643	specifically stimulates the peroxisome proliferator-activated receptor-alpha increasing MCD expression and activity in heart and skeletal muscle	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	troglitazone, a specific peroxisome proliferator-activated receptor-gamma agonist, decreases MCD expression, no effect on MCD activity	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Malonyl-CoA	Rattus norvegicus	degradation of malonyl-CoA, MCD is regulated both transcriptionally and posttranscriptionally, fatty acids induce MCD gene expression	Acetyl-CoA + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Sprague-Dawley rats, dietary manipulated	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Malonyl-CoA	-	Rattus norvegicus	Acetyl-CoA + CO2	-	?
Malonyl-CoA	degradation of malonyl-CoA, MCD is regulated both transcriptionally and posttranscriptionally, fatty acids induce MCD gene expression	Rattus norvegicus	Acetyl-CoA + CO2	-	?

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Release 2023.1 (January 2023)