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Literature summary for 4.1.1.65 extracted from
- The obligate intracellular parasite Toxoplasma gondii secretes a soluble phosphatidylserine decarboxylase (2012), J. Biol. Chem., 287, 22938-22947.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.067 | - |
phosphatidyl-L-serine | in 60 mM potassium phosphate (pH 6.8), 0.17 M sucrose, 0.35 mM phenylmethylsulfonyl fluoride, 2 mM EDTA, 0.5 mM 2-mercaptoethanol, at 37°C | Toxoplasma gondii |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Toxoplasma gondii | - |
- |
| vacuole | parasitophorous vacuole | Toxoplasma gondii | 5773 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 108000 | - |
x * 108000, proenzyme, calculated from amino acid sequence | Toxoplasma gondii |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Phosphatidyl-L-serine | Toxoplasma gondii | liposomal phosphatidyl-L-serine | Phosphatidylethanolamine + CO2 | - |
? | |
| Phosphatidyl-L-serine | Toxoplasma gondii TaTi | liposomal phosphatidyl-L-serine | Phosphatidylethanolamine + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Toxoplasma gondii | - |
- |
- |
| Toxoplasma gondii TaTi | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Phosphatidyl-L-serine | liposomal phosphatidyl-L-serine | Toxoplasma gondii | Phosphatidylethanolamine + CO2 | - |
? | |
| Phosphatidyl-L-serine | liposomal phosphatidyl-L-serine | Toxoplasma gondii TaTi | Phosphatidylethanolamine + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 108000, proenzyme, calculated from amino acid sequence | Toxoplasma gondii |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PSD1 | - |
Toxoplasma gondii |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Toxoplasma gondii | the specific enzyme activity increases by 3fold during the replication of Toxoplasma gondii | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | isoform PSD1 reduces externalized phosphatidylserine on host cells, enabling evasion of phagocytosis | Toxoplasma gondii |
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Release 2023.1 (January 2023)
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