Literature summary for 4.1.1.63 extracted from

Johnson, C.W.; Salvachua, D.; Khanna, P.; Smith, H.; Peterson, D.J.; Beckham, G.T.
Enhancing muconic acid production from glucose and lignin-derived aromatic compounds via increased protocatechuate decarboxylase activity (2016), Metab. Eng. Commun., 3, 111-119 .

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Application

Application	Comment	Organism
synthesis	engineering of Pseudomonas putida KT2440 to produce muconate from either aromatic molecules or sugars. Coexpression of protocatechuate decarboxylase and associated proteins reduces protocatechuate accumulation and enhances muconate production relative to strains expressing the protocatechuate decarboxylase alone. In bioreactor experiments, coexpression increases the specific productivity of muconate from the lignin monomer p-coumarate by 50% and results in a titer of >15 g/l. In strains engineered to produce muconate from glucose, coexpression more than triples the titer, yield, productivity, and specific productivity, with the best strain producing 4.92±0.48 g/l muconate	Enterobacter cloacae subsp. cloacae

Organism

Organism	UniProt	Comment	Textmining
Enterobacter cloacae subsp. cloacae	A0A0H3CJN8	-	-
Enterobacter cloacae subsp. cloacae DSM 30054	A0A0H3CJN8	-	-

Synonyms

Synonyms	Comment	Organism
ECL_01944	-	Enterobacter cloacae subsp. cloacae

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Release 2023.1 (January 2023)