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Literature summary for 4.1.1.53 extracted from

  • Lovenberg, W.; Weissbach, H.; Udenfriend, S.
    Aromatic L-amino acid decarboxylase (1962), J. Biol. Chem., 237, 89-93.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Benzene stimulates decarboxylation of natural amino acids Cavia aperea

Inhibitors

Inhibitors Comment Organism Structure
5-hydroxytryptophan complete inhibition at 0.001 mM Cavia aperea
alpha-Methyl-3,4-dihydroxyphenylalanine competitive Cavia aperea
alpha-Methyl-5-hydroxyphenylalanine
-
Cavia aperea
alpha-Methyl-m-tyrosine
-
Cavia aperea
alpha-Methyltryptophan
-
Cavia aperea
p-chloromercuribenzoate complete inhibition at 0.01 mM Cavia aperea

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3
-
tryptophan
-
Cavia aperea
1.3
-
p-tyrosine
-
Cavia aperea
0.002
-
5-hydroxytryptophan
-
Cavia aperea
0.04
-
3,4-dihydroxyphenylalanine
-
Cavia aperea
2
-
phenylalanine
-
Cavia aperea
2.2
-
histidine
-
Cavia aperea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cavia aperea involved in amine formation from natural amino acids prior to excretion ?
-
?

Organism

Organism UniProt Comment Textmining
Canis lupus
-
dog
-
Cavia aperea
-
guinea pig
-

Purification (Commentary)

Purification (Comment) Organism
-
Cavia aperea
brain stem enzyme, partial Canis lupus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Cavia aperea
-
liver
-
Canis lupus
-
kidney
-
Cavia aperea
-
kidney
-
Canis lupus
-
stomach
-
Cavia aperea
-
brain
-
Canis lupus
-

Storage Stability

Storage Stability Organism
3¦C, 0.03 M phosphate buffer, pH 7, 40% loss of activity after 10 days, purified enzyme Cavia aperea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information involved in amine formation from natural amino acids prior to excretion Cavia aperea ?
-
?
5-Hydroxytryptophan
-
Cavia aperea Serotonin + CO2
-
?
5-Hydroxytryptophan
-
Canis lupus Serotonin + CO2
-
?
L-phenylalanine
-
Cavia aperea phenylethylamine + CO2
-
?
L-phenylalanine
-
Canis lupus phenylethylamine + CO2
-
?
L-Tyrosine
-
Cavia aperea Tyramine + CO2
-
?
L-Tyrosine
-
Canis lupus Tyramine + CO2
-
?
3,4-Dihydroxyphenylalanine
-
Cavia aperea Dopamine + CO2
-
?
3,4-Dihydroxyphenylalanine
-
Canis lupus Dopamine + CO2
-
?
Tryptophan
-
Cavia aperea Tryptamine + CO2
-
?
Tryptophan
-
Canis lupus Tryptamine + CO2
-
?
Histidine
-
Cavia aperea Histamine + CO2
-
?
Histidine
-
Canis lupus Histamine + CO2
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
enzyme assay at Cavia aperea

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
Cavia aperea

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Cavia aperea
pyridoxal 5'-phosphate
-
Canis lupus