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Literature summary for 4.1.1.50 extracted from
- S-Adenosylmethionine decarboxylase (2009), Essays Biochem., 46, 25-45.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not activated by putrescine | Solanum tuberosum | |
| pi' subunit | - |
Trypanosoma brucei | |
| pi' subunit | - |
Trypanosoma cruzi | |
| putrescine | - |
Homo sapiens |  |
| putrescine | - |
Saccharomyces cerevisiae | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine | - |
Bacillus subtilis | |
| (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine | - |
Catharanthus roseus | |
| (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine | - |
Clostridium acetobutylicum | |
| (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine | - |
Escherichia coli | |
| (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine | - |
Homo sapiens | |
| (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine | - |
Methanocaldococcus jannaschii | |
| (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine | - |
Saccharomyces cerevisiae | |
| (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine | - |
Solanum tuberosum | |
| (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine | - |
Thermotoga maritima | |
| (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine | - |
Trypanosoma brucei | |
| (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine | - |
Trypanosoma cruzi | |
| 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine | - |
Bacillus subtilis | |
| 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine | - |
Catharanthus roseus | |
| 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine | - |
Clostridium acetobutylicum | |
| 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine | - |
Escherichia coli | |
| 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine | - |
Homo sapiens | |
| 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine | - |
Methanocaldococcus jannaschii | |
| 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine | - |
Saccharomyces cerevisiae | |
| 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine | - |
Solanum tuberosum | |
| 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine | - |
Thermotoga maritima | |
| 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine | - |
Trypanosoma brucei | |
| 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine | - |
Trypanosoma cruzi | |
| 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine | - |
Bacillus subtilis | |
| 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine | - |
Catharanthus roseus | |
| 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine | - |
Clostridium acetobutylicum | |
| 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine | - |
Escherichia coli | |
| 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine | - |
Homo sapiens | |
| 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine | - |
Methanocaldococcus jannaschii | |
| 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine | - |
Saccharomyces cerevisiae | |
| 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine | - |
Solanum tuberosum | |
| 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine | - |
Thermotoga maritima | |
| 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine | - |
Trypanosoma brucei | |
| 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine | - |
Trypanosoma cruzi | |
| 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine | - |
Bacillus subtilis | |
| 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine | - |
Catharanthus roseus | |
| 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine | - |
Clostridium acetobutylicum | |
| 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine | - |
Escherichia coli | |
| 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine | - |
Homo sapiens | |
| 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine | - |
Methanocaldococcus jannaschii | |
| 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine | - |
Saccharomyces cerevisiae | |
| 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine | - |
Solanum tuberosum | |
| 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine | - |
Thermotoga maritima | |
| 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine | - |
Trypanosoma brucei | |
| 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine | - |
Trypanosoma cruzi | |
| 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine | MDL 73811 | Bacillus subtilis | |
| 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine | MDL 73811 | Catharanthus roseus | |
| 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine | MDL 73811 | Clostridium acetobutylicum | |
| 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine | MDL 73811 | Escherichia coli | |
| 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine | MDL 73811 | Homo sapiens | |
| 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine | MDL 73811 | Methanocaldococcus jannaschii | |
| 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine | MDL 73811 | Saccharomyces cerevisiae | |
| 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine | MDL 73811 | Solanum tuberosum | |
| 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine | MDL 73811 | Thermotoga maritima | |
| 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine | MDL 73811 | Trypanosoma brucei | |
| 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine | MDL 73811 | Trypanosoma cruzi | |
| Genz-644131 | i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine | Bacillus subtilis | |
| Genz-644131 | i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine | Catharanthus roseus | |
| Genz-644131 | i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine | Clostridium acetobutylicum | |
| Genz-644131 | i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine | Escherichia coli | |
| Genz-644131 | i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine | Homo sapiens | |
| Genz-644131 | i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine | Methanocaldococcus jannaschii | |
| Genz-644131 | i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine | Saccharomyces cerevisiae | |
| Genz-644131 | i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine | Solanum tuberosum | |
| Genz-644131 | i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine | Thermotoga maritima | |
| Genz-644131 | i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine | Trypanosoma brucei | |
| Genz-644131 | i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine | Trypanosoma cruzi | |
| methylglyoxal bis(guanylhydrazone) | - |
Bacillus subtilis | |
| methylglyoxal bis(guanylhydrazone) | - |
Catharanthus roseus | |
| methylglyoxal bis(guanylhydrazone) | - |
Clostridium acetobutylicum | |
| methylglyoxal bis(guanylhydrazone) | - |
Escherichia coli | |
| methylglyoxal bis(guanylhydrazone) | - |
Homo sapiens | |
| methylglyoxal bis(guanylhydrazone) | - |
Methanocaldococcus jannaschii | |
| methylglyoxal bis(guanylhydrazone) | - |
Saccharomyces cerevisiae | |
| methylglyoxal bis(guanylhydrazone) | - |
Solanum tuberosum | |
| methylglyoxal bis(guanylhydrazone) | - |
Thermotoga maritima | |
| methylglyoxal bis(guanylhydrazone) | - |
Trypanosoma brucei | |
| methylglyoxal bis(guanylhydrazone) | - |
Trypanosoma cruzi | |
| SAM486A | previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone | Bacillus subtilis | |
| SAM486A | previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone | Catharanthus roseus | |
| SAM486A | previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone | Clostridium acetobutylicum | |
| SAM486A | previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone | Escherichia coli | |
| SAM486A | previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone | Homo sapiens | |
| SAM486A | previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone | Methanocaldococcus jannaschii | |
| SAM486A | previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone | Saccharomyces cerevisiae | |
| SAM486A | previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone | Solanum tuberosum | |
| SAM486A | previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone | Thermotoga maritima | |
| SAM486A | previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone | Trypanosoma brucei | |
| SAM486A | previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone | Trypanosoma cruzi | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Escherichia coli | |
| Mg2+ | required | Clostridium acetobutylicum | |
| additional information | does not require Mg2+ for activity | Bacillus subtilis | |
| additional information | does not require Mg2+ for activity | Homo sapiens | |
| additional information | does not require Mg2+ for activity | Saccharomyces cerevisiae | |
| additional information | does not require Mg2+ for activity | Solanum tuberosum | |
| additional information | does not require Mg2+ for activity | Trypanosoma brucei | |
| additional information | does not require Mg2+ for activity | Trypanosoma cruzi | |
| additional information | does not require Mg2+ for activity | Methanocaldococcus jannaschii | |
| additional information | does not require Mg2+ for activity | Catharanthus roseus | |
| additional information | does not require Mg2+ for activity | Thermotoga maritima |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 14000 | - |
estimated from amino acid sequence | Bacillus subtilis |
| 14000 | - |
estimated from amino acid sequence | Methanocaldococcus jannaschii |
| 15000 | - |
estimated from amino acid sequence | Thermotoga maritima |
| 30000 | - |
estimated from amino acid sequence | Escherichia coli |
| 32000 | - |
estimated from amino acid sequence | Clostridium acetobutylicum |
| 38000 | - |
estimated from amino acid sequence | Homo sapiens |
| 39000 | - |
estimated from amino acid sequence | Catharanthus roseus |
| 40000 | - |
estimated from amino acid sequence | Solanum tuberosum |
| 42000 | - |
estimated from amino acid sequence | Trypanosoma cruzi |
| 44000 | - |
estimated from amino acid sequence | Trypanosoma brucei |
| 46000 | - |
estimated from amino acid sequence | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Catharanthus roseus | - |
- |
- |
| Clostridium acetobutylicum | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Methanocaldococcus jannaschii | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Solanum tuberosum | - |
- |
- |
| Thermotoga maritima | - |
- |
- |
| Trypanosoma brucei | - |
- |
- |
| Trypanosoma cruzi | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine | - |
Bacillus subtilis | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Escherichia coli | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Homo sapiens | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Saccharomyces cerevisiae | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Solanum tuberosum | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Trypanosoma brucei | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Trypanosoma cruzi | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Clostridium acetobutylicum | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Methanocaldococcus jannaschii | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Catharanthus roseus | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Thermotoga maritima | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | x-ray crystallography | Bacillus subtilis |
| heterodimer | x-ray crystallography | Escherichia coli |
| heterodimer | x-ray crystallography | Homo sapiens |
| heterodimer | x-ray crystallography | Saccharomyces cerevisiae |
| heterodimer | x-ray crystallography | Solanum tuberosum |
| heterodimer | x-ray crystallography | Trypanosoma brucei |
| heterodimer | x-ray crystallography | Trypanosoma cruzi |
| heterodimer | x-ray crystallography | Clostridium acetobutylicum |
| heterodimer | x-ray crystallography | Methanocaldococcus jannaschii |
| heterodimer | x-ray crystallography | Catharanthus roseus |
| heterodimer | x-ray crystallography | Thermotoga maritima |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AdoMet decarboxylase | - |
Bacillus subtilis |
| AdoMet decarboxylase | - |
Escherichia coli |
| AdoMet decarboxylase | - |
Homo sapiens |
| AdoMet decarboxylase | - |
Saccharomyces cerevisiae |
| AdoMet decarboxylase | - |
Solanum tuberosum |
| AdoMet decarboxylase | - |
Trypanosoma brucei |
| AdoMet decarboxylase | - |
Trypanosoma cruzi |
| AdoMet decarboxylase | - |
Clostridium acetobutylicum |
| AdoMet decarboxylase | - |
Methanocaldococcus jannaschii |
| AdoMet decarboxylase | - |
Catharanthus roseus |
| AdoMet decarboxylase | - |
Thermotoga maritima |
| AdoMetDC | - |
Bacillus subtilis |
| AdoMetDC | - |
Escherichia coli |
| AdoMetDC | - |
Homo sapiens |
| AdoMetDC | - |
Saccharomyces cerevisiae |
| AdoMetDC | - |
Solanum tuberosum |
| AdoMetDC | - |
Trypanosoma brucei |
| AdoMetDC | - |
Trypanosoma cruzi |
| AdoMetDC | - |
Clostridium acetobutylicum |
| AdoMetDC | - |
Methanocaldococcus jannaschii |
| AdoMetDC | - |
Catharanthus roseus |
| AdoMetDC | - |
Thermotoga maritima |
| S-Adenosylmethionine decarboxylase | - |
Bacillus subtilis |
| S-Adenosylmethionine decarboxylase | - |
Escherichia coli |
| S-Adenosylmethionine decarboxylase | - |
Homo sapiens |
| S-Adenosylmethionine decarboxylase | - |
Saccharomyces cerevisiae |
| S-Adenosylmethionine decarboxylase | - |
Solanum tuberosum |
| S-Adenosylmethionine decarboxylase | - |
Trypanosoma brucei |
| S-Adenosylmethionine decarboxylase | - |
Trypanosoma cruzi |
| S-Adenosylmethionine decarboxylase | - |
Clostridium acetobutylicum |
| S-Adenosylmethionine decarboxylase | - |
Methanocaldococcus jannaschii |
| S-Adenosylmethionine decarboxylase | - |
Catharanthus roseus |
| S-Adenosylmethionine decarboxylase | - |
Thermotoga maritima |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Bacillus subtilis | |
| pyridoxal 5'-phosphate | - |
Escherichia coli | |
| pyridoxal 5'-phosphate | - |
Homo sapiens | |
| pyridoxal 5'-phosphate | - |
Saccharomyces cerevisiae | |
| pyridoxal 5'-phosphate | - |
Solanum tuberosum | |
| pyridoxal 5'-phosphate | - |
Trypanosoma brucei | |
| pyridoxal 5'-phosphate | - |
Trypanosoma cruzi | |
| pyridoxal 5'-phosphate | - |
Clostridium acetobutylicum | |
| pyridoxal 5'-phosphate | - |
Methanocaldococcus jannaschii | |
| pyridoxal 5'-phosphate | - |
Catharanthus roseus | |
| pyridoxal 5'-phosphate | - |
Thermotoga maritima | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Bacillus subtilis | AdoMetDC is negatively regulated by spermidine and spermine | down |
| Escherichia coli | AdoMetDC is negatively regulated by spermidine and spermine | down |
| Homo sapiens | AdoMetDC is negatively regulated by spermidine and spermine | down |
| Saccharomyces cerevisiae | AdoMetDC is negatively regulated by spermidine and spermine | down |
| Solanum tuberosum | AdoMetDC is negatively regulated by spermidine and spermine | down |
| Trypanosoma brucei | AdoMetDC is negatively regulated by spermidine and spermine | down |
| Trypanosoma cruzi | AdoMetDC is negatively regulated by spermidine and spermine | down |
| Clostridium acetobutylicum | AdoMetDC is negatively regulated by spermidine and spermine | down |
| Methanocaldococcus jannaschii | AdoMetDC is negatively regulated by spermidine and spermine | down |
| Catharanthus roseus | AdoMetDC is negatively regulated by spermidine and spermine | down |
| Thermotoga maritima | AdoMetDC is negatively regulated by spermidine and spermine | down |
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