Literature summary for 4.1.1.50 extracted from

Schaefer, B.; Hauber, I.; Bunk, A.; Heukeshoven, J.; Duesedau, A.; Bevec, D.; Hauber, J.
Inhibition of multidrug-resistant HIV-1 by interference with cellular S-adenosylmethionine decarboxylase activity (2006), J. Infect. Dis., 194, 740-750.

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Application

Application	Comment	Organism
medicine	enzyme inhibitor (2E)-2-[4-[amino(imino)methyl]-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide, i.e. CGP48664A, SAM486A, suppresses HIV-1 replication, including the replication of viruses that are resistant to multiple reverse transcriptase and protease inhibitos. Antiretroviral effect is based on the fact that regulatory protein Rev activity is severely compromised in drug-treated cells. No toxic effects on cellular metabolism are observed	Human immunodeficiency virus 1

Inhibitors

Inhibitors	Comment	Organism	Structure
(2E)-2-[4-[amino(imino)methyl]-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide	i.e. CGP48664A, SAM486A, active site inhibitor, in addition suppresses HIV-1 replication	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

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Release 2023.1 (January 2023)