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BRENDA support

Literature summary for 4.1.1.48 extracted from

  • O'Rourke, K.; Jelowicki, A.; Boehr, D.
    Controlling active site loop dynamics in the (beta/alpha)8 barrel enzyme indole-3-glycerol phosphate synthase (2016), Catalysts, 6, 129 .
No PubMed abstract available

Protein Variants

Protein Variants Comment Organism
R64A/D65A mutation disrupts interactions on the C-terminal side of the beta1alpha1 loop and decreases catalytic efficiency, slows down the dehydration step and quenches loop dynamics Saccharolobus solfataricus
R64A/D65A/N90A mutation leads to new micros-ms timescale loop dynamics and makes the ring-closure step rate-determining once again Saccharolobus solfataricus

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q06121
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Saccharolobus solfataricus DSM 1617 Q06121
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Synonyms

Synonyms Comment Organism
SSO0895 locus name Saccharolobus solfataricus
TrpC
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Saccharolobus solfataricus