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Literature summary for 4.1.1.48 extracted from

  • Mazumder-Shivakumar, D.; Bruice, T.C.
    Molecular dynamics studies of ground state and intermediate of the hyperthermophilic indole-3-glycerol phosphate synthase (2004), Proc. Natl. Acad. Sci. USA, 101, 14379-14384.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q06121
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Reaction

Reaction Comment Organism Reaction ID
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O molecular dynamics study at different temperatures. K110 is the general acid, E210 the general base. At higher temperature, the enzyme-substrate electrostatic interaction favors the binding of the substrate in near attack conformation, at lower temperature, the substrate is bound in nonreactive conformation Saccharolobus solfataricus