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Literature summary for 4.1.1.45 extracted from

  • Brundin, L.; Sellgren, C.; Lim, C.; Grit, J.; Palsson, E.; Landen, M.; Samuelsson, M.; Lundgren, K.; Brundin, P.; Fuchs, D.; Postolache, T.; Traskman-Bendz, L.; Guillemin, G.; Erhardt, S.
    An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation (2016), Transl. Psychiatry, 6, e865 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine increased quinolic acid levels may result from reduced activity of ACMSD in suicidal subjects. Suicide attempters have reduced picolinic acid levels and a decreased picolinic acid/quinolinic acid ratio in both cerebrospinal fluid and blood. The minor C allele of the ACMSD SNP rs2121337 is more prevalent in suicide attempters and associated with increased cerebrospinal quinolinic acid level Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TDX5
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Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
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 Homo sapiens
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cerebrospinal fluid
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function amino-beta-carboxymuconate-semialdehyde-decarboxylase limits quinolinic acid formation by competitive production of the neuroprotective metabolite picolinic acid. Decreased ACMSD activity can lead to excess quinolinic acid Homo sapiens