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Literature summary for 4.1.1.4 extracted from

  • Han, B.; Gopalan, V.; Ezeji, T.C.
    Acetone production in solventogenic Clostridium species: new insights from non-enzymatic decarboxylation of acetoacetate (2011), Appl. Microbiol. Biotechnol., 91, 565-576.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene aadc encoded in the sol operon, cloning of gene fragments aadc358-1 and aadc358-2 in Escherichia coli strain DH5alpha, expression as GFP-tagged enzyme Clostridium beijerinckii
gene aadc, cloning in Escherichia coli strain DH5alpha, expression as GFP-tagged enzyme Clostridium acetobutylicum

Protein Variants

Protein Variants Comment Organism
additional information generation of an aadc deletion mutant, the mutant produces a maximum acetone concentration comparable to that produced by wild-type. Non-enzymatic decarboxylation of acetoacetate in vitro, under conditions similar to in vivo acetone-butanol-ethanol fermentation, produces 1.3 to 5.2 g/L acetone between pH 4.0-6.5 and explains why various knock-out and knockdown strategies designed to disrupt aadc in solventogenic Clostridium species do not eliminate acetone production during acetone-butanol-ethanol fermentation Clostridium beijerinckii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetoacetate + H+ Clostridium acetobutylicum
-
acetone + CO2
-
?
acetoacetate + H+ Clostridium beijerinckii
-
acetone + CO2
-
?
acetoacetate + H+ Clostridium beijerinckii NCIMB 8052
-
acetone + CO2
-
?

Organism

Organism UniProt Comment Textmining
Clostridium acetobutylicum P23670 gene aadc
-
Clostridium beijerinckii A6M020 gene aadc
-
Clostridium beijerinckii NCIMB 8052 A6M020 gene aadc
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetoacetate + H+
-
Clostridium acetobutylicum acetone + CO2
-
?
acetoacetate + H+
-
Clostridium beijerinckii acetone + CO2
-
?
acetoacetate + H+ the AADC activity relies on measurement of CO2 produced as a result of AADC-catalyzed decarboxylation of acetoacetate Clostridium acetobutylicum acetone + CO2
-
?
acetoacetate + H+ the AADC activity relies on measurement of CO2 produced as a result of AADC-catalyzed decarboxylation of acetoacetate Clostridium beijerinckii acetone + CO2
-
?
acetoacetate + H+
-
Clostridium beijerinckii NCIMB 8052 acetone + CO2
-
?
acetoacetate + H+ the AADC activity relies on measurement of CO2 produced as a result of AADC-catalyzed decarboxylation of acetoacetate Clostridium beijerinckii NCIMB 8052 acetone + CO2
-
?

Synonyms

Synonyms Comment Organism
AADC
-
Clostridium acetobutylicum
AADC
-
Clostridium beijerinckii

General Information

General Information Comment Organism
physiological function enzyme AADC-catalyzed decarboxylation of acetoacetate is not the sole means for acetone generation Clostridium beijerinckii