Literature summary for 4.1.1.4 extracted from

Ravagnani, A.; Jennert, K.C.B.; Steiner, E.; Grunberg, R.; Jefferies, J.R.; Wilkinson, S.R.; Young, D.I.; Tidswell, E.C.; Brown, D.P.; Youngman, P.; Morris, J.G.; Young M.
Spo0A directly controls the switch from acid to solvent production in solvent-forming clostridia (2000), Mol. Microbiol., 37, 1172-1185.

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Activating Compound

Activating Compound	Comment	Organism	Structure
acetate	in pH-controlled cultures, the addition of 20 mM acetate promotes a more vigorous solventogenic fermentation	Clostridium beijerinckii
Butyrate	in pH-controlled cultures, the addition of 20 mM acetate promotes a more vigorous solventogenic fermentation	Clostridium beijerinckii
spo0A	in gel retardation assays, the C-terminal domains of Spo0A is able to bind fragments of acetoacetate decarboxylase promoter, Spo0A directly controls the shift between acidogenesis and solventogenesis, insertional inactivation of spo0A blocked the formation of solvents	Clostridium beijerinckii

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetoacetate + H+	Clostridium beijerinckii	-	acetone + CO2	-	?
acetoacetate + H+	Clostridium acetobutylicum	-	acetone + CO2	-	?
acetoacetate + H+	Ruminiclostridium cellulolyticum	-	acetone + CO2	-	?
acetoacetate + H+	Clostridium beijerinckii NCIMB 8052	-	acetone + CO2	-	?
acetoacetate + H+	Clostridium beijerinckii AA243	-	acetone + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Clostridium acetobutylicum	-	ATCC 824	-
Clostridium beijerinckii	-	NCIMB 8052	-
Clostridium beijerinckii	-	no activity	-
Clostridium beijerinckii AA243	-	no activity	-
Clostridium beijerinckii NCIMB 8052	-	NCIMB 8052	-
Ruminiclostridium cellulolyticum	-	ATCC 35319	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetoacetate + H+	-	Clostridium beijerinckii	acetone + CO2	-	?
acetoacetate + H+	-	Clostridium acetobutylicum	acetone + CO2	-	?
acetoacetate + H+	-	Ruminiclostridium cellulolyticum	acetone + CO2	-	?
acetoacetate + H+	-	Clostridium beijerinckii NCIMB 8052	acetone + CO2	-	?
acetoacetate + H+	-	Clostridium beijerinckii AA243	acetone + CO2	-	?

Synonyms

Synonyms	Comment	Organism
acetoacetic acid decarboxylase	-	Clostridium beijerinckii
acetoacetic acid decarboxylase	-	Clostridium acetobutylicum
acetoacetic acid decarboxylase	-	Ruminiclostridium cellulolyticum

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Release 2023.1 (January 2023)