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Literature summary for 4.1.1.37 extracted from

  • McDonagh, B.; Pedrajas, J.R.; Padilla, C.A.; Barcena, J.A.
    Thiol redox sensitivity of two key enzymes of heme biosynthesis and pentose phosphate pathways: uroporphyrinogen decarboxylase and transketolase (2013), Oxid. Med. Cell. Longev., 2013, 932472.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Uroporphyrinogen III Saccharomyces cerevisiae
-
Coproporphyrinogen III + 4 CO2
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P32347
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glutathionylation Cys52 of the enzyme can be glutathionylated and subsequently deglutathionylated by Grx2p in vitro Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Uroporphyrinogen III
-
Saccharomyces cerevisiae Coproporphyrinogen III + 4 CO2
-
?

Synonyms

Synonyms Comment Organism
Hem12p
-
Saccharomyces cerevisiae

General Information

General Information Comment Organism
metabolism uroporphyrinogen decarboxylase, Hem12p, is involved in the 5th step of heme biosynthesis in the cytosol, before biosynthesis is completed within mitochondria Saccharomyces cerevisiae