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Literature summary for 4.1.1.36 extracted from

  • Petrenyi, K.; Molero, C.; Konya, Z.; Erdodi, F.; Arino, J.; Dombradi, V.
    Analysis of two putative Candida albicans phosphopantothenoylcysteine decarboxylase / protein phosphatase Z regulatory subunits reveals an unexpected distribution of functional roles (2016), PLoS ONE, 11, e0160965 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Candida albicans A0A1D8PKD2 and Q5A868 A0A1D8PKD2 i.e. subunit Hal3, Q5A868 i.e. subunit Cab3
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Synonyms

Synonyms Comment Organism
Cab3 phosphopantothenoylcysteine decarboxylase complex subunit Candida albicans
Hal3 phosphopantothenoylcysteine decarboxylase complex subunit Candida albicans

General Information

General Information Comment Organism
physiological function both recombinant subunits Hal3 and Cab3 are able to bind and inhibit Candida albicans protein phosphatase Z (Ppz1) as well as its C-terminal catalytic domain with comparable efficiency. Both subunits Hal3 and Cab3 are essential components of phosphopantothenoylcysteine decarboxylase. Expression of Cab3 and Hal3 rescues the cab3 and hal3 vhs3 Saccharomyces cerevisiae mutations, respectively Candida albicans