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Literature summary for 4.1.1.36 extracted from

  • Kupke, T.; Hernandez-Acosta, P.; Steinbacher, S.; Culianez-Macia, F.A.
    Arabidopsis thaliana flavoprotein AtHAL3a catalyzes the decarboxylation of 4'-phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis (2001), J. Biol. Chem., 276, 19190-19196.
    View publication on PubMed
Search for more literature for 4.1.1.36

Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli

Protein Variants

Protein Variants Comment Organism
C158A constructed by sequential polymerase chain reaction Escherichia coli
H90N exchange leads to complete inactivation of the enzyme Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-4'-phospho-N-pantothenoylcysteine Escherichia coli
-
 4'-phosphopantetheine + CO2
-
 ?
N-[(R)-4'-phosphopantothenoyl]-L-cysteine Arabidopsis thaliana key step in coenzyme A biosynthesis pantotheine 4'-phosphate + CO2
-
 ?
N-[(R)-4'-phosphopantothenoyl]-L-cysteine Escherichia coli key step in coenzyme A biosynthestic pathway pantotheine 4'-phosphate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9SWE5
-
-
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli
-
 Arabidopsis thaliana

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-4'-phospho-N-pantothenoylcysteine
-
 Escherichia coli 4'-phosphopantetheine + CO2
-
 ?
N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 Escherichia coli pantotheine 4'-phosphate + CO2
-
 ?
N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 Arabidopsis thaliana pantotheine 4'-phosphate + CO2
-
 ?
N-[(R)-4'-phosphopantothenoyl]-L-cysteine key step in coenzyme A biosynthesis Arabidopsis thaliana pantotheine 4'-phosphate + CO2
-
 ?
N-[(R)-4'-phosphopantothenoyl]-L-cysteine key step in coenzyme A biosynthestic pathway Escherichia coli pantotheine 4'-phosphate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
Dfp
-
 Escherichia coli
flavoprotein AtHal3a
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
flavin flavoprotein Escherichia coli