BRENDA - Enzyme Database show
show all sequences of 4.1.1.36

Pantothenoylcysteine-4'-phosphate decarboxylase from horse liver

Scandurra, R.; Barboni, E.; Granata, F.; Pensa, B.; Costa, M.; Eur. J. Biochem. 49, 1-9 (1974)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
2-mercaptoethanol
increases activity
Equus caballus
cysteine
-
Rattus norvegicus
cysteine
increases activity
Equus caballus
DTT
increases activity
Equus caballus
Inhibitors
Inhibitors
Commentary
Organism
Structure
4,4-Bis(dimethylaminodiphenylcarbinol)
-
Rattus norvegicus
hydroxylamine
-
Equus caballus
iodoacetamide
-
Equus caballus
NaBH4
-
Equus caballus
phenylhydrazine
-
Equus caballus
pyridoxal 5'-phosphate
-
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.43
-
4-phosphopantothenoyl-L-Cys
-
Equus caballus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
intracellular
not bound to any cellular structure
Equus caballus
5622
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Equus caballus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-
Purification (Commentary)
Commentary
Organism
-
Equus caballus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
heart
-
Bos taurus
-
heart
-
Equus caballus
-
heart
-
Sus scrofa
-
kidney
-
Bos taurus
-
kidney
-
Equus caballus
-
kidney
-
Oryctolagus cuniculus
-
kidney
-
Sus scrofa
-
kidney
-
Rattus norvegicus
-
liver
-
Bos taurus
-
liver
-
Oryctolagus cuniculus
-
liver
-
Sus scrofa
-
liver
-
Rattus norvegicus
-
liver
-
Equus caballus
-
muscle
-
Bos taurus
-
muscle
-
Equus caballus
-
muscle
-
Sus scrofa
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.089
-
-
Equus caballus
Storage Stability
Storage Stability
Organism
stable for at least 2 months if frozen as diluted solution, less than 1 mg/ml, or concentrated solution, 1-10 mg/ml
Equus caballus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
N-((R)-4-Phosphopantothenoyl)-L-Cys
-
4408
Rattus norvegicus
Pantotheine 4-phosphate + CO2
-
4408
Rattus norvegicus
-
N-((R)-4-Phosphopantothenoyl)-L-Cys
-
4408
Sus scrofa
Pantotheine 4-phosphate + CO2
-
4408
Sus scrofa
-
N-((R)-4-Phosphopantothenoyl)-L-Cys
-
4408
Bos taurus
Pantotheine 4-phosphate + CO2
-
4408
Bos taurus
-
N-((R)-4-Phosphopantothenoyl)-L-Cys
-
4408
Oryctolagus cuniculus
Pantotheine 4-phosphate + CO2
-
4408
Oryctolagus cuniculus
-
N-((R)-4-Phosphopantothenoyl)-L-Cys
specific for
4408
Equus caballus
Pantotheine 4-phosphate + CO2
-
4408
Equus caballus
-
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.6
-
-
Equus caballus
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6
9.5
pH 9.5: 75% of optimal activity, pH 6: 23% of optimal activity
Equus caballus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
2-mercaptoethanol
increases activity
Equus caballus
cysteine
-
Rattus norvegicus
cysteine
increases activity
Equus caballus
DTT
increases activity
Equus caballus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
4,4-Bis(dimethylaminodiphenylcarbinol)
-
Rattus norvegicus
hydroxylamine
-
Equus caballus
iodoacetamide
-
Equus caballus
NaBH4
-
Equus caballus
phenylhydrazine
-
Equus caballus
pyridoxal 5'-phosphate
-
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.43
-
4-phosphopantothenoyl-L-Cys
-
Equus caballus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
intracellular
not bound to any cellular structure
Equus caballus
5622
-
Purification (Commentary) (protein specific)
Commentary
Organism
-
Equus caballus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
heart
-
Bos taurus
-
heart
-
Equus caballus
-
heart
-
Sus scrofa
-
kidney
-
Bos taurus
-
kidney
-
Equus caballus
-
kidney
-
Oryctolagus cuniculus
-
kidney
-
Sus scrofa
-
kidney
-
Rattus norvegicus
-
liver
-
Bos taurus
-
liver
-
Oryctolagus cuniculus
-
liver
-
Sus scrofa
-
liver
-
Rattus norvegicus
-
liver
-
Equus caballus
-
muscle
-
Bos taurus
-
muscle
-
Equus caballus
-
muscle
-
Sus scrofa
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.089
-
-
Equus caballus
Storage Stability (protein specific)
Storage Stability
Organism
stable for at least 2 months if frozen as diluted solution, less than 1 mg/ml, or concentrated solution, 1-10 mg/ml
Equus caballus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
N-((R)-4-Phosphopantothenoyl)-L-Cys
-
4408
Rattus norvegicus
Pantotheine 4-phosphate + CO2
-
4408
Rattus norvegicus
-
N-((R)-4-Phosphopantothenoyl)-L-Cys
-
4408
Sus scrofa
Pantotheine 4-phosphate + CO2
-
4408
Sus scrofa
-
N-((R)-4-Phosphopantothenoyl)-L-Cys
-
4408
Bos taurus
Pantotheine 4-phosphate + CO2
-
4408
Bos taurus
-
N-((R)-4-Phosphopantothenoyl)-L-Cys
-
4408
Oryctolagus cuniculus
Pantotheine 4-phosphate + CO2
-
4408
Oryctolagus cuniculus
-
N-((R)-4-Phosphopantothenoyl)-L-Cys
specific for
4408
Equus caballus
Pantotheine 4-phosphate + CO2
-
4408
Equus caballus
-
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.6
-
-
Equus caballus
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6
9.5
pH 9.5: 75% of optimal activity, pH 6: 23% of optimal activity
Equus caballus
Other publictions for EC 4.1.1.36
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
749093
Petrenyi
Analysis of two putative Cand ...
Candida albicans
PLoS ONE
11
e0160965
2016
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1
1
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727536
Afshar
A recessive X-linked mutation ...
Drosophila melanogaster
FEBS Open Bio
3
302-304
2013
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5
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1
1
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702179
Zhang
Role of OsHAL3 protein, a puta ...
Oryza sativa
Biochemistry (Moscow)
74
61-67
2009
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1
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2
-
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1
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4
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705844
Sun
OsHAL3 mediates a new pathway ...
Oryza sativa
Nat. Cell Biol.
11
845-851
2009
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705847
Ruiz
Moonlighting proteins Hal3 and ...
Saccharomyces cerevisiae
Nat. Chem. Biol.
5
920-928
2009
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1
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1
1
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1
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677979
Kumar
How pantothenol intervenes in ...
Mycobacterium tuberculosis
Biochem. Biophys. Res. Commun.
361
903-909
2007
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1
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1
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674749
Kupke
4-Phosphopantetheine biosynthe ...
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661
J. Biol. Chem.
281
5435-5444
2006
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1
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10
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2
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4
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1
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2
1
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1
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1
1
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10
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1
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2
1
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682401
Rubio
An Arabidopsis mutant impaired ...
Arabidopsis thaliana
Plant Physiol.
140
830-843
2006
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3
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1
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664025
Strauss
Mechanistic studies on phospho ...
Homo sapiens
Biochemistry
43
15520-15533
2004
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1
1
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2
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1
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1
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1
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1
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1
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665867
Yonamine
Overexpression of NtHAL3 genes ...
Nicotiana tabacum
J. Exp. Bot.
55
387-395
2004
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2
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6
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1
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1
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1
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3
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648959
Manoj
Structure of human phosphopant ...
Homo sapiens
Structure
11
927-936
2003
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1
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649215
Manoj
Unusual space-group pseudosymm ...
Homo sapiens
Acta Crystallogr. Sect. D
59
1762-1766
2003
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1
1
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1
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3
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1
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650566
Strauss
Stereochemical studies on phos ...
Escherichia coli
Bioorg. Med. Chem. Lett.
13
339-342
2003
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1
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1
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1
1
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1
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1
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2
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652908
Steinbacher
Crystal structure of the plant ...
Arabidopsis thaliana
J. Mol. Biol.
327
193-202
2003
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1
1
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1
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3
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1
1
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2
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652261
Hernandez-Acosta
Molecular characterization of ...
Arabidopsis thaliana
J. Biol. Chem.
277
20490-20498
2002
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1
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6
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2
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3
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1
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3
1
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1
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1
1
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6
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2
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1
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3
1
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651576
Strauss
Mechanistic studies on phospho ...
Escherichia coli
J. Am. Chem. Soc.
123
6449-6450
2001
-
-
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1
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1
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1
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1
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1
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1
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1
-
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652126
Kupke
Arabidopsis thaliana flavoprot ...
Arabidopsis thaliana, Escherichia coli
J. Biol. Chem.
276
19190-19196
2001
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1
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2
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3
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5
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2
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5
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1
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1
1
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2
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2
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5
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652148
Kupke
Molecular characterization of ...
Escherichia coli
J. Biol. Chem.
276
27597-27604
2001
-
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1
-
6
-
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-
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2
1
-
3
-
-
1
-
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-
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-
2
1
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Scandurra
Functional residues at the act ...
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4414
Scandurra
Covalently bound pyruvate in p ...
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4415
Yang
Purification and properties of ...
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Aberhart
Coenzyme A biosynthesis: Steri ...
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1985
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4411
Scandurra
Phosphopantothenoylcysteine de ...
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Brohn
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4408
Scandurra
Pantothenoylcysteine-4'-phosph ...
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Abiko
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