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Literature summary for 4.1.1.35 extracted from
- Functional cloning and characterization of a UDP-glucuronic acid decarboxylase: the pathogenic fungus Cryptococcus neoformans elucidates UDP-xylose synthesis (2001), Proc. Natl. Acad. Sci. USA, 98, 12003-12008.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene UXS1 cloned and expressed in Escherichia coli BL21 (DE3)pLysS | Cryptococcus neoformans |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CaCl2 | slight inhibition | Cryptococcus neoformans |  |
| MgCl2 | slight inhibition | Cryptococcus neoformans | |
| MnCl2 | slight inhibition | Cryptococcus neoformans | |
| NADH | not affected by NADP+, only slightly inhibited by NADPH | Cryptococcus neoformans | |
| UDP | - |
Cryptococcus neoformans | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | metal ions are not required | Cryptococcus neoformans |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 46500 | - |
predicted from amino acid sequence | Cryptococcus neoformans |
| 47000 | - |
recombinant enzyme, bacterial expressed | Cryptococcus neoformans |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cryptococcus neoformans | Q96V00 | pathogenic fungus | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cryptococcus neoformans |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, stable for several months | Cryptococcus neoformans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-D-glucuronate | - |
Cryptococcus neoformans | UDP-D-xylose + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronic acid decarboxylase | - |
Cryptococcus neoformans |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Cryptococcus neoformans |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 23 | 42 | - |
Cryptococcus neoformans |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Cryptococcus neoformans |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8.5 | - |
Cryptococcus neoformans |
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