Literature summary for 4.1.1.34 extracted from

  • Kagawa, Y.; Shimazono, N.
    Catabolism of L-ascorbate in animal tissues (1970), Methods Enzymol., 18, 46-50.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
8-hydroxyquinoline Mn2+ or Mg2+ restore activity Rattus norvegicus
diisopropylfluorophosphate
-
Rattus norvegicus
Metal chelating agents
-
Rattus norvegicus
monoiodoacetate
-
Rattus norvegicus
PCMB
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-Diketo-L-gulonic acid Rattus norvegicus enzyme is involved in the catabolism of L-ascorbate ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
-20°C, partially purified enzyme, stable for months Rattus norvegicus
0°C, purified enzyme, stable for 1 week Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-Diketo-D-gulonic acid
-
Rattus norvegicus D-Xylulose + CO2
-
?
2,3-Diketo-L-gulonic acid
-
Rattus norvegicus D-Xylonic acid + CO2
-
?
2,3-Diketo-D-gluconic acid
-
Rattus norvegicus ?
-
?
2,3-Diketo-L-gluconic acid
-
Rattus norvegicus ?
-
?
2,3-Diketo-D-glucoheptonic acid
-
Rattus norvegicus ?
-
?
2,3-Diketo-D-pentonic acid
-
Rattus norvegicus ?
-
?
2,3-Diketo-L-pentonic acid
-
Rattus norvegicus ?
-
?
2,3-Diketo-L-gulonic acid enzyme is involved in the catabolism of L-ascorbate Rattus norvegicus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Rattus norvegicus