Literature summary for 4.1.1.32 extracted from

Yang, J.; Kong, X.; Martins-Santos, M.E.; Aleman, G.; Chaco, E.; Liu, G.E.; Wu, S.Y.; Samols, D.; Hakimi, P.; Chiang, C.M.; Hanson, R.W.
Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha (2009), J. Biol. Chem., 284, 27042-27053.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Mus musculus	5829	-
cytosol	-	Homo sapiens	5829	-
cytosol	-	Rattus norvegicus	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
AML-12 cell	-	Mus musculus	-
FTO-2B cell	-	Rattus norvegicus	-
Hep-G2 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + oxaloacetate	-	Mus musculus	GDP + phosphoenolpyruvate + CO2	-	?
GTP + oxaloacetate	-	Homo sapiens	GDP + phosphoenolpyruvate + CO2	-	?
GTP + oxaloacetate	-	Rattus norvegicus	GDP + phosphoenolpyruvate + CO2	-	?

Synonyms

Synonyms	Comment	Organism
PEPCK-C	cytosolic form	Mus musculus
PEPCK-C	cytosolic form	Homo sapiens
PEPCK-C	cytosolic form	Rattus norvegicus
phosphoenolpyruvate carboxykinase	-	Mus musculus
phosphoenolpyruvate carboxykinase	-	Homo sapiens
phosphoenolpyruvate carboxykinase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
GTP	-	Mus musculus
GTP	-	Homo sapiens
GTP	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Mus musculus	activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha. Isonicotinamide decreases the level of mRNA for PEPCK-C	down
Rattus norvegicus	activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha. Isonicotinamide decreases the level of mRNA for PEPCK-C	down
Homo sapiens	activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha. Isonicotinamide decreases the level of mRNA for PEPCK-C with an IC50 of 2.3 mM	down

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Release 2023.1 (January 2023)