Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | PEPCK mRNA is elevated in cells cultured at high density, expression is induced by contact inhibition in the presence of serum, at low culture density, dexamethasone induces PEPCK mRNA 5-8fold, at high culture density 2-3fold | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | insulin is a potent dominant repressor of PEPCK gene transcription and causes a rapid decrease of PEPCK mRNA | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + oxaloacetate | Rattus norvegicus | catalyzes the rate-limiting step in gluconeogenesis, PEPCK expression and growth arrest may be coordinately regulated | GDP + phosphoenolpyruvate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatoma cell line | H4IIEC3 cells, mRNA is 5-10fold elevated in cells cultured at high density compared to low density, KRC-7 cells, an H4IIEC3 subclone, are much more sensitive to growth arrest than its parental cell line | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + oxaloacetate | - |
Rattus norvegicus | GDP + phosphoenolpyruvate + CO2 | - |
? | |
GTP + oxaloacetate | catalyzes the rate-limiting step in gluconeogenesis, PEPCK expression and growth arrest may be coordinately regulated | Rattus norvegicus | GDP + phosphoenolpyruvate + CO2 | - |
? | |
ITP + oxaloacetate | - |
Rattus norvegicus | IDP + phosphoenolpyruvate + CO2 | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |