Literature summary for 4.1.1.28 extracted from

Cunningham, J.; Pivirotto, P.; Bringas, J.; Suzuki, B.; Vijay, S.; Sanftner, L.; Kitamura, M.; Chan, C.; Bankiewicz, K.S.
Biodistribution of adeno-associated virus type-2 in nonhuman primates after convection-enhanced delivery to brain (2008), Mol. Ther., 16, 1267-1275.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	relative to obtained dose of Adeno-associated virus type 2 including human AADC gene, high dose-dependent levels of cDNA are detected	Homo sapiens

Application

Application	Comment	Organism
medicine	combination treatment of Adeno-associated virus type-2 containing human AADC gene, with oral levodopa is a novel therapeutic approach in patients with Parkinson disease	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
human AADC gene is cloned into a Adeno-associated virus type 2 shuttle plasmid, and a recombinant Adeno-associated virus type 2 containing hAADC under the control of the cytomegalovirus promoter is generated by a triple transfection technique	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-3,4-Dihydroxyphenylalanine	Homo sapiens	L-dopa, levodopa, AADC constitutes the last enzymatic step in the biosynthesis of dopamine	Dopamine + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	Macaca mulatta with parkinsonian syndrome, infused with different doses of adeno-associated virus type 2 including human AADC gene	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-3,4-Dihydroxyphenylalanine	L-dopa, levodopa, AADC constitutes the last enzymatic step in the biosynthesis of dopamine	Homo sapiens	Dopamine + CO2	-	?

Synonyms

Synonyms	Comment	Organism
AADC	-	Homo sapiens
Aromatic L-amino acid decarboxylase	-	Homo sapiens

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Release 2023.1 (January 2023)