Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.28 extracted from

  • Avgeris, M.; Koutalellis, G.; Fragoulis, E.G.; Scorilas, A.
    Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) inprostate cancer (2008), Clin. Biochem., 41, 1140-1149.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information DDC is overexpressed, at the mRNA level, in the specimens from prostate cancer patients, in comparison to those from benign prostate hyperplasia patients. High expression levels of DDC are found more frequently in high Gleason's score tumors as well as in advanced stage patients. Homo sapiens

Application

Application Comment Organism
medicine potential of DDC expression, at the mRNA level, as a novel biomarker in prostate cancer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-Hydroxytryptophan Homo sapiens
-
Serotonin + CO2 neurotransmitter ?
L-Dopa Homo sapiens
-
dopamine + CO2
-
?
additional information Homo sapiens L-dopa decarboxylase is a pyridoxal 5'-phosphate-dependent enzyme involved in many malignancies ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell prostate cancer Homo sapiens
-
prostate cancer cell line LNCaP cell Homo sapiens
-
prostate gland total RNA is isolated from tissue specimens from benign prostate hyperplasia and prostate cancer patients Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-Hydroxytryptophan
-
Homo sapiens Serotonin + CO2 neurotransmitter ?
L-Dopa
-
Homo sapiens dopamine + CO2
-
?
additional information L-dopa decarboxylase is a pyridoxal 5'-phosphate-dependent enzyme involved in many malignancies Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
homodimer
-
Homo sapiens

Synonyms

Synonyms Comment Organism
AADC
-
Homo sapiens
Aromatic L-amino acid decarboxylase
-
Homo sapiens
DDC
-
Homo sapiens
L-DOPA decarboxylase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Homo sapiens