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Literature summary for 4.1.1.28 extracted from

  • Facchini, P.J.; Huber-Allanach, K.L.; Tari, L.W.
    Plant aromatic L-amino acid decarboxylases: evolution, biochemistry, regulation, and metabolic engineering applications (2000), Phytochemistry, 54, 121-138.
    View publication on PubMed
Search for more literature for 4.1.1.28

Application

Application Comment Organism
pharmacology biosynthesis of pharmaceutically important monoterpenoid indole alkaloids Drosophila melanogaster
pharmacology biosynthesis of pharmaceutically important monoterpenoid indole alkaloids Sus scrofa
pharmacology biosynthesis of pharmaceutically important monoterpenoid indole alkaloids Solanum lycopersicum
pharmacology biosynthesis of pharmaceutically important monoterpenoid indole alkaloids Cinchona calisaya
pharmacology biosynthesis of pharmaceutically important monoterpenoid indole alkaloids Catharanthus roseus
pharmacology biosynthesis of pharmaceutically important monoterpenoid indole alkaloids Cinchona officinalis
pharmacology biosynthesis of pharmaceutically important monoterpenoid indole alkaloids Camptotheca acuminata
pharmacology biosynthesis of pharmaceutically important monoterpenoid indole alkaloids Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Drosophila melanogaster
-
 Sus scrofa
-
 Solanum lycopersicum
-
 Cinchona calisaya
-
 Cinchona officinalis
-
 Homo sapiens
TDC encoded by a single-copy gene,TDC gene used to transform tobacco, Canola and potato plants and callus and root cultures from Peganum harmala Catharanthus roseus
two autonomously regulated genes, TDC1 and TDC2 Camptotheca acuminata

Inhibitors

Inhibitors Comment Organism Structure
D-tryptophan non-competitive inhibitor Catharanthus roseus
tryptamine competitive inhibitor Catharanthus roseus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
 2 * 54000 Catharanthus roseus
115000
-
-
 Catharanthus roseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan Sus scrofa
-
 tryptamine + CO2
-
 ?
L-tryptophan Homo sapiens
-
 tryptamine + CO2
-
 ?
L-tryptophan Solanum lycopersicum implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines tryptamine + CO2
-
 ?
L-tryptophan Cinchona calisaya implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines tryptamine + CO2
-
 ?
L-tryptophan Catharanthus roseus implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines tryptamine + CO2
-
 ?
L-tryptophan Cinchona officinalis implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines tryptamine + CO2
-
 ?
L-tryptophan Camptotheca acuminata implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines tryptamine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Camptotheca acuminata P93082
-
-
Catharanthus roseus P17770
-
-
Cinchona calisaya
-
-
-
Cinchona officinalis
-
-
-
Drosophila melanogaster
-
 fruit fly
-
Homo sapiens P20711 human
-
Solanum lycopersicum
-
-
-
Sus scrofa
-
 pig
-

Purification (Commentary)

Purification (Comment) Organism
-
 Catharanthus roseus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-fluoro-L-tryptophan
-
 Catharanthus roseus 4-fluorotryptamine + CO2
-
 ?
4-methyl-L-tryptophan
-
 Catharanthus roseus 4-methyltryptamine + CO2
-
 ?
5-fluoro-L-tryptophan
-
 Catharanthus roseus 5-fluorotryptamine + CO2
-
 ?
5-hydroxy-L-tryptophan
-
 Solanum lycopersicum 5-hydroxytryptamine + CO2
-
 ?
5-hydroxy-L-tryptophan
-
 Cinchona calisaya 5-hydroxytryptamine + CO2
-
 ?
5-hydroxy-L-tryptophan
-
 Catharanthus roseus 5-hydroxytryptamine + CO2
-
 ?
5-hydroxy-L-tryptophan
-
 Camptotheca acuminata 5-hydroxytryptamine + CO2
-
 ?
5-hydroxy-L-tryptophan
-
 Homo sapiens 5-hydroxytryptamine + CO2
-
 ?
5-hydroxytryptophan
-
 Cinchona officinalis 5-hydroxytryptamine + CO2
-
 ?
L-Dopa
-
 Drosophila melanogaster dopamine + CO2
-
 ?
L-Dopa
-
 Sus scrofa dopamine + CO2
-
 ?
L-Dopa
-
 Homo sapiens dopamine + CO2
-
 ?
L-tryptophan
-
 Sus scrofa tryptamine + CO2
-
 ?
L-tryptophan
-
 Solanum lycopersicum tryptamine + CO2
-
 ?
L-tryptophan
-
 Cinchona calisaya tryptamine + CO2
-
 ?
L-tryptophan
-
 Catharanthus roseus tryptamine + CO2
-
 ?
L-tryptophan
-
 Cinchona officinalis tryptamine + CO2
-
 ?
L-tryptophan
-
 Camptotheca acuminata tryptamine + CO2
-
 ?
L-tryptophan
-
 Homo sapiens tryptamine + CO2
-
 ?
L-tryptophan implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines Solanum lycopersicum tryptamine + CO2
-
 ?
L-tryptophan implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines Cinchona calisaya tryptamine + CO2
-
 ?
L-tryptophan implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines Catharanthus roseus tryptamine + CO2
-
 ?
L-tryptophan implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines Cinchona officinalis tryptamine + CO2
-
 ?
L-tryptophan implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines Camptotheca acuminata tryptamine + CO2
-
 ?
additional information exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, L-tyrosine, L-phenylalanine and L-Dopa are not accepted as substrates Solanum lycopersicum ?
-
 ?
additional information exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, L-tyrosine, L-phenylalanine and L-Dopa are not accepted as substrates Cinchona calisaya ?
-
 ?
additional information exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, L-tyrosine, L-phenylalanine and L-Dopa are not accepted as substrates Catharanthus roseus ?
-
 ?
additional information exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, L-tyrosine, L-phenylalanine and L-Dopa are not accepted as substrates Cinchona officinalis ?
-
 ?
additional information exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, L-tyrosine, L-phenylalanine and L-Dopa are not accepted as substrates Camptotheca acuminata ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 54000 Catharanthus roseus

Synonyms

Synonyms Comment Organism
AADC
-
 Drosophila melanogaster
AADC
-
 Sus scrofa
AADC
-
 Solanum lycopersicum
AADC
-
 Cinchona calisaya
AADC
-
 Catharanthus roseus
AADC
-
 Cinchona officinalis
AADC
-
 Camptotheca acuminata
AADC
-
 Homo sapiens
CrTDC
-
 Catharanthus roseus
DDC
-
 Drosophila melanogaster
DDC
-
 Sus scrofa
DDC
-
 Homo sapiens
EC 4.1.1.27 formerly Solanum lycopersicum
EC 4.1.1.27 formerly Cinchona calisaya
EC 4.1.1.27 formerly Catharanthus roseus
EC 4.1.1.27 formerly Cinchona officinalis
EC 4.1.1.27 formerly Camptotheca acuminata
HsDDC
-
 Homo sapiens
L-amino acid decarboxylase
-
 Drosophila melanogaster
L-amino acid decarboxylase
-
 Sus scrofa
L-amino acid decarboxylase
-
 Solanum lycopersicum
L-amino acid decarboxylase
-
 Cinchona calisaya
L-amino acid decarboxylase
-
 Catharanthus roseus
L-amino acid decarboxylase
-
 Cinchona officinalis
L-amino acid decarboxylase
-
 Camptotheca acuminata
L-amino acid decarboxylase
-
 Homo sapiens
L-DOPA decarboxylase
-
 Drosophila melanogaster
L-DOPA decarboxylase
-
 Sus scrofa
L-DOPA decarboxylase
-
 Homo sapiens
L-Tryptophan decarboxylase
-
 Solanum lycopersicum
L-Tryptophan decarboxylase
-
 Cinchona calisaya
L-Tryptophan decarboxylase
-
 Catharanthus roseus
L-Tryptophan decarboxylase
-
 Cinchona officinalis
L-Tryptophan decarboxylase
-
 Camptotheca acuminata
TDC
-
 Solanum lycopersicum
TDC
-
 Cinchona calisaya
TDC
-
 Catharanthus roseus
TDC
-
 Cinchona officinalis
TDC
-
 Camptotheca acuminata
TDC2
-
 Camptotheca acuminata
tryptophan decarboxylase-1
-
 Camptotheca acuminata
tryptophan decarboxylase-2
-
 Camptotheca acuminata

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Drosophila melanogaster
pyridoxal 5'-phosphate
-
 Sus scrofa
pyridoxal 5'-phosphate
-
 Solanum lycopersicum
pyridoxal 5'-phosphate
-
 Cinchona calisaya
pyridoxal 5'-phosphate
-
 Catharanthus roseus
pyridoxal 5'-phosphate
-
 Cinchona officinalis
pyridoxal 5'-phosphate
-
 Camptotheca acuminata
pyridoxal 5'-phosphate
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.31
-
 tryptamine
-
 Catharanthus roseus

pI Value

Organism Comment pI Value Maximum pI Value
Catharanthus roseus
-
-
 5.9