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Literature summary for 4.1.1.28 extracted from
- Identification and characterization of an aromatic amino acid decarboxylase from the filarial nematode, Dirofilaria immitis (2001), Biol. Chem., 382, 115-122.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | increases enzyme activity greatly | Dirofilaria immitis |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not sensitive to diisopropyl flurophosphate | Dirofilaria immitis | |
| p-chloromercuribenzoic acid | - |
Dirofilaria immitis | |
| pefabloc | - |
Dirofilaria immitis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0291 | - |
L-tryptophanyl-7-amido-4-methylcoumarin | pH6.5-7.5, 37°C | Dirofilaria immitis | |
| 0.0321 | - |
L-phenylalanyl-7-amido-4-methylcoumarin | pH6.5-7.5, 37°C | Dirofilaria immitis | |
| 0.0351 | - |
Tyr-7-amido-4-methylcoumarin | pH6.5-7.5, 37°C | Dirofilaria immitis | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 48000 | - |
gel filtration, SDS-PAGE | Dirofilaria immitis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan | Dirofilaria immitis | - |
tryptamine + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dirofilaria immitis | - |
filarial nematode, causative agent of heartworm disease in dogs and cats | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Dirofilaria immitis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-phenylalanine | - |
Dirofilaria immitis | phenylethylamine + CO2 | - |
? | |
| L-tryptophan | - |
Dirofilaria immitis | tryptamine + CO2 | - |
? | |
| L-Tyrosine | - |
Dirofilaria immitis | Tyramine + CO2 | - |
? | |
| Phe-7-amido-4-methylcoumarin | - |
Dirofilaria immitis | ? + 7-amino-4-methylcoumarin | - |
? | |
| Trp-7-amido-4-methylcoumarin | - |
Dirofilaria immitis | ? + 7-amino-4-methylcoumarin | - |
? | |
| Tyr-7-amido-4-methylcoumarin | - |
Dirofilaria immitis | ? + 7-amino-4-methylcoumarin | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 48000, SDS-PAGE | Dirofilaria immitis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Aromatic amino acid decarboxylase | - |
Dirofilaria immitis |
| Di-ADC | - |
Dirofilaria immitis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no absolute requirement for exogenous pyridoxal 5'-phosphate | Dirofilaria immitis |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Dirofilaria immitis | isoelectric focusing | 5.9 | 5.6 |
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