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Literature summary for 4.1.1.28 extracted from

  • Borri Voltattorni, C.; Bertoldi, M.; Bianconi, S.; Deng, W.p.; Wong, K.; Kim, I.; Herbert, B.; Kirk, K.L.
    Behavior of fluorinated analogs of L-(3,4-dihydroxyphenyl)alanine and L-threo-(3,4-dihydroxyphenyl)serine as substrates for Dopa decarboxylase (2002), Biochem. Biophys. Res. Commun., 295, 107-111.
    View publication on PubMed
Search for more literature for 4.1.1.28

Application

Application Comment Organism
synthesis preparation of valuable biochemical and diagnostic tools Sus scrofa

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.091
-
 L-Dopa pH 6.8, 25°C Sus scrofa
0.7
-
 6-fluoro-DOPA pH 6.8, 25°C Sus scrofa
0.95
-
 2-fluoro-DOPA pH 6.8, 25°C Sus scrofa
3.35
-
 5-fluoro-DOPA pH 6.8, 25°C Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan Sus scrofa
-
 tryptamine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
 pig
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-fluoro-DOPA
-
 Sus scrofa ?
-
 ?
2-fluoro-L-(3,4-dihydroxyphenyl)alanine
-
 Sus scrofa 4-(2-aminoethyl)-3-fluorobenzene-1,2-diol + CO2
-
 ?
5-fluoro-DOPA
-
 Sus scrofa ?
-
 ?
5-fluoro-L-(3,4-dihydroxyphenyl)alanine
-
 Sus scrofa 5-(2-aminoethyl)-3-fluorobenzene-1,2-diol + CO2
-
 ?
6-fluoro-DOPA
-
 Sus scrofa ?
-
 ?
6-fluoro-L-(3,4-dihydroxyphenyl)alanine
-
 Sus scrofa 4-(2-aminoethyl)-5-fluorobenzene-1,2-diol + CO2
-
 ?
6-fluoro-threo-(3,4-dihydroxyphenyl)serine
-
 Sus scrofa 4-(2-aminoethyl)-5-fluorobenzene-1,2-diol + CO2
-
 ?
L-(3,4-dihydroxyphenyl)alanine
-
 Sus scrofa 4-(2-aminoethyl)benzene-1,2-diol + CO2
-
 ?
L-threo-(3,4-dihydroxyphenyl)serine
-
 Sus scrofa 4-[(2-hydroxyethyl)amino]benzene-1,2-diol + CO2
-
 ?
L-tryptophan
-
 Sus scrofa tryptamine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
DDC
-
 Sus scrofa
DOPA decarboxylase
-
 Sus scrofa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3 6 5-fluoro-DOPA pH 6.8, 25°C Sus scrofa
3.47
-
 5-fluoro-DOPA pH 6.8, 25°C Sus scrofa
5.2
-
 2-fluoro-DOPA pH 6.8, 25°C Sus scrofa
8.2
-
 6-fluoro-DOPA pH 6.8, 25°C Sus scrofa
9.1
-
 L-Dopa pH 6.8, 25°C Sus scrofa

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Sus scrofa