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Literature summary for 4.1.1.28 extracted from

  • Voltattorni, C.B.; Giartosio, A.; Turano, C.
    Aromatic-L-amino acid decarboxylase from pig kidney (1987), Methods Enzymol., 142, 179-187.
    View publication on PubMed
Search for more literature for 4.1.1.28

General Stability

General Stability Organism
graduall decrease in activity by repeated freezing and thawing Sus scrofa
no loss of activity after lyophilization Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
2,3,4-Trihydroxybenzylhydrazine
-
 Sus scrofa
Amino-oxyacetate
-
 Sus scrofa
BH4
-
 Sus scrofa
Dithiobisnitrobenzoate
-
 Sus scrofa
DL-alpha-Difluoromethyl-beta-(3,4-dihydroxyphenyl)alanine
-
 Sus scrofa
DL-alpha-Monofluoromethyl-beta-(3,4-dihydroxyphenyl)alanine
-
 Sus scrofa
hydroxylamine
-
 Sus scrofa
iodoacetamide
-
 Sus scrofa
L-alpha-Methyl-alpha-hydrazino-3,4-dihydroxyphenylpropionic acid
-
 Sus scrofa
mercuribenzoate
-
 Sus scrofa
NEM
-
 Sus scrofa
Semicarbazide
-
 Sus scrofa
Thiosemicarbazide
-
 Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.12
-
 L-o-Tyr
-
 Sus scrofa
0.18
-
 3,4-dihydroxyphenylalanine
-
 Sus scrofa
0.23
-
 5-hydroxytryptophan
-
 Sus scrofa
0.52
-
 L-m-Tyr
-
 Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 2 * 50000, SDS-PAGE Sus scrofa
103000
-
 ultracentrifugation analysis Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Sus scrofa

Storage Stability

Storage Stability Organism
-20°C, 0.1 M potassium phosphate buffer, 0.1 mM dithiothreitol, stable for at least 2 months Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-Dihydroxyphenylalanine
-
 Sus scrofa 3-Hydroxytyramine + CO2
-
 ?
5-Hydroxytryptophan
-
 Sus scrofa Serotonin + CO2
-
 ?
m-Tyr
-
 Sus scrofa ?
-
 ?
o-Tyr
-
 Sus scrofa ?
-
 ?
Tyr
-
 Sus scrofa ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 50000, SDS-PAGE Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
-
 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate 1 mol of pyridoxal 5'-phosphate is bound to the epsilon-amino group of a lysyl residue of the apoenzyme Sus scrofa