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Literature summary for 4.1.1.28 extracted from
- Aromatic L-amino acid decarboxylase (guinea pig kidney) (1971), Methods Enzymol., 17B, 652-656.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Benzene | stimulates | Cavia porcellus |  |
| chloroform | stimulates | Cavia porcellus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-Methyl-5-hydroxytryptophan | - |
Cavia porcellus | |
| DL-alpha-Monofluoromethyl-beta-(3,4-dihydroxyphenyl)alanine | - |
Cavia porcellus | |
| PCMB | - |
Cavia porcellus | |
| Semicarbazide | - |
Cavia porcellus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
5-hydroxytryptophan | - |
Cavia porcellus | |
| 0.4 | - |
3,4-dihydroxyphenylalanine | - |
Cavia porcellus | |
| 3 | - |
Trp | - |
Cavia porcellus | |
| 13 | - |
Tyr | - |
Cavia porcellus | |
| 20 | - |
Phe | - |
Cavia porcellus | |
| 22 | - |
His | - |
Cavia porcellus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cavia porcellus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Cavia porcellus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 35.95 | - |
- |
Cavia porcellus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 40% loss of activity after 10 days | Cavia porcellus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,4-Dihydroxyphenylalanine | - |
Cavia porcellus | 3-Hydroxytyramine + CO2 | - |
? | |
| 5-Hydroxytryptophan | - |
Cavia porcellus | Serotonin + CO2 | - |
? | |
| His | - |
Cavia porcellus | ? | - |
? | |
| L-Phe | - |
Cavia porcellus | phenylethylamine + CO2 | - |
? | |
| L-Trp | - |
Cavia porcellus | Tryptamine + CO2 | - |
? | |
| m-Tyr | - |
Cavia porcellus | ? | - |
? | |
| additional information | no significant activity towards aliphatic amino acids | Cavia porcellus | ? | - |
? | |
| o-Tyr | - |
Cavia porcellus | ? | - |
? | |
| Tyr | - |
Cavia porcellus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
- |
Cavia porcellus |
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Release 2023.1 (January 2023)
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