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Literature summary for 4.1.1.25 extracted from

  • Lan, X.; Chang, K.; Zeng, L.; Liu, X.; Qiu, F.; Zheng, W.; Quan, H.; Liao, Z.; Chen, M.; Huang, W.; Liu, W.; Wang, Q.
    Engineering salidroside biosynthetic pathway in hairy root cultures of Rhodiola crenulata based on metabolic characterization of tyrosine decarboxylase (2013), PLoS ONE, 8, e75459.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
synthesis engineering of a salidroside biosynthetic pathway in Rhodiola crenulata hairy roots via metabolic engineering strategy of overexpression. All the transgenic lines show much higher expression levels of tyrosine decaboxylase than non-transgenic one. The transgenic lines produce tyramine, tyrosol and salidroside at higher levels, which are respectively 3.21–6.84, 1.50–2.19 and 1.27–3.47 folds compared with the corresponding compound in non-transgenic lines Rhodiola crenulata

Organism

Organism UniProt Comment Textmining
Rhodiola crenulata I7B4Z2
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Source Tissue

Source Tissue Comment Organism Textmining
flower higher expression levels in leaves than in flowers and roots Rhodiola crenulata
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leaf higher expression levels in leaves than in flowers and roots Rhodiola crenulata
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additional information gene expressing levels are consistent with the salidroside accumulation levels Rhodiola crenulata
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root higher expression levels in leaves than in flowers and roots Rhodiola crenulata
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stem highest expression Rhodiola crenulata
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Synonyms

Synonyms Comment Organism
TYDC
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 Rhodiola crenulata

Expression

Organism Comment Expression
Rhodiola crenulata gene expression is induced coordinately with the expression of UDP-glucuronosyltransferase, the last gene involved in salidroside biosynthesis, in salicylic acid/methyl jasmonate treatment. The expression of both enzymes is dramatically upregulated by salicylic acid, respectively 49 folds and 36 folds compared with control. Methyl jasmonate also significantly increases their expression in hairy root cultures up