Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-deoxy-2'-fluoro-6-iodo-beta-D-uridine 5'-O-monophosphate | - |
Homo sapiens | |
2'-deoxy-2'-fluoro-6-iodo-beta-D-uridine 5'-O-monophosphate | - |
Methanothermobacter thermautotrophicus | |
2'-deoxy-2'-fluoro-6-iodo-UMP | - |
Homo sapiens | |
2'-deoxy-2'-fluoro-6-iodo-UMP | - |
Methanothermobacter thermautotrophicus | |
2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl-cytosine | - |
Homo sapiens | |
2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl-cytosine | - |
Methanothermobacter thermautotrophicus | |
5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | - |
Homo sapiens | |
5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | - |
Methanothermobacter thermautotrophicus | |
6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | poor inhibitor | Homo sapiens | |
6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | poor inhibitor | Methanothermobacter thermautotrophicus | |
6-amino-5-fluorouridine | competitive inhibition at submicromolar concentrations | Homo sapiens | |
6-amino-5-fluorouridine | competitive inhibition at submicromolar concentrations | Methanothermobacter thermautotrophicus | |
6-azauridine | potent inhibitor | Homo sapiens | |
6-azauridine | potent inhibitor | Methanothermobacter thermautotrophicus | |
6-azido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | - |
Homo sapiens | |
6-azido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | - |
Methanothermobacter thermautotrophicus | |
6-azido-5-fluorouridine | irreversible inhibitor | Homo sapiens | |
6-azido-5-fluorouridine | irreversible inhibitor | Methanothermobacter thermautotrophicus | |
6-azido-UMP | - |
Homo sapiens | |
6-azido-UMP | - |
Methanothermobacter thermautotrophicus | |
6-carbamoyl-UMP | - |
Methanothermobacter thermautotrophicus | |
6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | reversible inhibitor | Homo sapiens | |
6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | reversible inhibitor | Methanothermobacter thermautotrophicus | |
6-cyanouridine | - |
Homo sapiens | |
6-cyanouridine | - |
Methanothermobacter thermautotrophicus | |
6-hydroxyuridine | potent inhibitor | Homo sapiens | |
6-hydroxyuridine | potent inhibitor | Methanothermobacter thermautotrophicus | |
6-iodouridine | - |
Homo sapiens | |
6-iodouridine | - |
Methanothermobacter thermautotrophicus | |
6-thiocarboxamidouridine | potent inhibitor | Homo sapiens | |
6-thiocarboxamidouridine | potent inhibitor | Methanothermobacter thermautotrophicus | |
clevudine | - |
Homo sapiens | |
clevudine | - |
Methanothermobacter thermautotrophicus | |
gemcitabine | - |
Homo sapiens | |
gemcitabine | - |
Methanothermobacter thermautotrophicus | |
nifedipine | competitive inhibitor | Homo sapiens | |
nifedipine | competitive inhibitor | Methanothermobacter thermautotrophicus | |
nimodipine | competitive inhibitor | Homo sapiens | |
nimodipine | competitive inhibitor | Methanothermobacter thermautotrophicus | |
pyrazofurin | potent inhibitor | Homo sapiens | |
pyrazofurin | potent inhibitor | Methanothermobacter thermautotrophicus | |
Xanthosine | potent inhibitor | Homo sapiens | |
Xanthosine | potent inhibitor | Methanothermobacter thermautotrophicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Methanothermobacter thermautotrophicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Orotidine 5'-phosphate | - |
Homo sapiens | UMP + CO2 | - |
? | |
Orotidine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | UMP + CO2 | - |
? | |
orotidine 5'-phosphate + H+ | - |
Homo sapiens | UMP + CO2 | - |
? | |
orotidine 5'-phosphate + H+ | - |
Methanothermobacter thermautotrophicus | UMP + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ODCase | - |
Homo sapiens |
ODCase | - |
Methanothermobacter thermautotrophicus |
OMPDCase | - |
Homo sapiens |
OMPDCase | - |
Methanothermobacter thermautotrophicus |
Orotidine 5'-monophosphate decarboxylase | - |
Homo sapiens |
Orotidine 5'-monophosphate decarboxylase | - |
Methanothermobacter thermautotrophicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00132 | - |
6-carbamoyl-UMP | in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C | Methanothermobacter thermautotrophicus | |
0.0286 | - |
6-cyanouridine | in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C | Methanothermobacter thermautotrophicus | |
0.037 | - |
6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C | Methanothermobacter thermautotrophicus | |
0.204 | - |
6-cyanouridine | in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C | Homo sapiens | |
0.36 | - |
5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C | Methanothermobacter thermautotrophicus | |
0.759 | - |
5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C | Homo sapiens | |
2 | - |
6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | Ki above 2 mM, in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C | Homo sapiens | |
3.322 | - |
6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C | Methanothermobacter thermautotrophicus | |
4 | - |
6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate | Ki above 4 mM, in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C | Homo sapiens |