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Literature summary for 4.1.1.23 extracted from
- Structures of the human orotidine-5-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design (2008), Structure, 16, 82-92.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| nine crystal structures of human OMPD in complex with substrate, product and nucleotide inhibitors are described | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-bromo-UMP | - |
Homo sapiens |  |
| 5-fluoro-UMP | - |
Homo sapiens | |
| 5-iodo-UMP | - |
Homo sapiens | |
| 6-hydroxymethyl-UMP | - |
Homo sapiens | |
| 6-iodo-UMP | - |
Homo sapiens | |
| UMP | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0166 | - |
orotidine 5'-phosphate | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Orotidine 5'-phosphate | Homo sapiens | - |
UMP + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P11172 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Orotidine 5'-phosphate | - |
Homo sapiens | UMP + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| OMPD | - |
Homo sapiens |
| Orotidine-5'-monophosphate decarboxylase | - |
Homo sapiens |
| orotidine-5'-phosphate decarboxylase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
activity assay | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.75 | - |
orotidine 5'-phosphate | - |
Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
activity assay | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
pseudo-IC50 value IUMP is a covalent inhibitor | Homo sapiens | 6-iodo-UMP | |
| 0.1 | - |
- |
Homo sapiens | 5-bromo-UMP | |
| 0.25 | - |
- |
Homo sapiens | 5-iodo-UMP | |
| 0.32 | - |
- |
Homo sapiens | 5-fluoro-UMP | |
| 0.4 | - |
- |
Homo sapiens | UMP | |
| 0.45 | - |
no complete inhibition | Homo sapiens | 6-hydroxymethyl-UMP | |
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