Cloned (Comment) | Organism |
---|---|
- |
Methanothermobacter thermautotrophicus |
- |
Plasmodium falciparum |
Crystallization (Comment) | Organism |
---|---|
the crystal structures of Plasmodium falciparum ODCase in complex with 6-I-UMP, 6-N3-UMP and 6-NH2-UMP are solved at resolutions of 1.95, 1.90 and 1.8 A, respectively | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-amino-uridine 5'-monophosphate | - |
Plasmodium falciparum | |
6-aminouridine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | |
6-aza-uridine 5'-monophosphate | - |
Plasmodium falciparum | |
6-azauridine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | |
6-azido-uridine 5'-monophosphate | - |
Plasmodium falciparum | |
6-azidouridine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | |
6-cyano-uridine 5'-monophosphate | - |
Plasmodium falciparum | |
6-cyanouridine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | |
6-methyl-uridine 5'-monophosphate | - |
Plasmodium falciparum | |
6-methyluridine 5'-phosphate | - |
Methanothermobacter thermautotrophicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Orotidine 5'-phosphate | Methanothermobacter thermautotrophicus | - |
UMP + CO2 | - |
? | |
Orotidine 5'-phosphate | Plasmodium falciparum | - |
UMP + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methanothermobacter thermautotrophicus | - |
- |
- |
Plasmodium falciparum | Q8IJH3 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Methanothermobacter thermautotrophicus |
- |
Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Orotidine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | UMP + CO2 | - |
? | |
Orotidine 5'-phosphate | - |
Plasmodium falciparum | UMP + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ODCase | - |
Methanothermobacter thermautotrophicus |
ODCase | - |
Plasmodium falciparum |
Orotidine 5'-monophosphate decarboxylase | - |
Methanothermobacter thermautotrophicus |
Orotidine 5'-monophosphate decarboxylase | - |
Plasmodium falciparum |
Orotidine monophosphate decarboxylase | - |
Methanothermobacter thermautotrophicus |
Orotidine monophosphate decarboxylase | - |
Plasmodium falciparum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
activity assay | Plasmodium falciparum |
55 | - |
activity assay | Methanothermobacter thermautotrophicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
activity assay | Methanothermobacter thermautotrophicus |
7.5 | - |
activity assay | Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00019 | - |
6-azidouridine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | |
0.00084 | - |
6-aminouridine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | |
0.0011 | - |
6-aza-uridine 5'-monophosphate | - |
Plasmodium falciparum | |
0.002 | - |
6-azido-uridine 5'-monophosphate | - |
Plasmodium falciparum | |
0.0021 | - |
6-amino-uridine 5'-monophosphate | - |
Plasmodium falciparum | |
0.0124 | - |
6-azauridine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | |
0.026 | - |
6-cyano-uridine 5'-monophosphate | - |
Plasmodium falciparum | |
0.029 | - |
6-cyanouridine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | |
0.0341 | - |
6-methyl-uridine 5'-monophosphate | - |
Plasmodium falciparum | |
0.134 | - |
6-methyluridine 5'-phosphate | - |
Methanothermobacter thermautotrophicus |