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Literature summary for 4.1.1.23 extracted from

  • Bello, A.M.; Poduch, E.; Liu, Y.; Wei, L.; Crandall, I.; Wang, X.; Dyanand, C.; Kain, K.C.; Pai, E.F.; Kotra, L.P.
    Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase (2008), J. Med. Chem., 51, 439-448.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Methanothermobacter thermautotrophicus
-
Plasmodium falciparum

Crystallization (Commentary)

Crystallization (Comment) Organism
the crystal structures of Plasmodium falciparum ODCase in complex with 6-I-UMP, 6-N3-UMP and 6-NH2-UMP are solved at resolutions of 1.95, 1.90 and 1.8 A, respectively Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
6-amino-uridine 5'-monophosphate
-
Plasmodium falciparum
6-aminouridine 5'-phosphate
-
Methanothermobacter thermautotrophicus
6-aza-uridine 5'-monophosphate
-
Plasmodium falciparum
6-azauridine 5'-phosphate
-
Methanothermobacter thermautotrophicus
6-azido-uridine 5'-monophosphate
-
Plasmodium falciparum
6-azidouridine 5'-phosphate
-
Methanothermobacter thermautotrophicus
6-cyano-uridine 5'-monophosphate
-
Plasmodium falciparum
6-cyanouridine 5'-phosphate
-
Methanothermobacter thermautotrophicus
6-methyl-uridine 5'-monophosphate
-
Plasmodium falciparum
6-methyluridine 5'-phosphate
-
Methanothermobacter thermautotrophicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Orotidine 5'-phosphate Methanothermobacter thermautotrophicus
-
UMP + CO2
-
?
Orotidine 5'-phosphate Plasmodium falciparum
-
UMP + CO2
-
?

Organism

Organism UniProt Comment Textmining
Methanothermobacter thermautotrophicus
-
-
-
Plasmodium falciparum Q8IJH3
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Methanothermobacter thermautotrophicus
-
Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Orotidine 5'-phosphate
-
Methanothermobacter thermautotrophicus UMP + CO2
-
?
Orotidine 5'-phosphate
-
Plasmodium falciparum UMP + CO2
-
?

Synonyms

Synonyms Comment Organism
ODCase
-
Methanothermobacter thermautotrophicus
ODCase
-
Plasmodium falciparum
Orotidine 5'-monophosphate decarboxylase
-
Methanothermobacter thermautotrophicus
Orotidine 5'-monophosphate decarboxylase
-
Plasmodium falciparum
Orotidine monophosphate decarboxylase
-
Methanothermobacter thermautotrophicus
Orotidine monophosphate decarboxylase
-
Plasmodium falciparum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
activity assay Plasmodium falciparum
55
-
activity assay Methanothermobacter thermautotrophicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
activity assay Methanothermobacter thermautotrophicus
7.5
-
activity assay Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00019
-
6-azidouridine 5'-phosphate
-
Methanothermobacter thermautotrophicus
0.00084
-
6-aminouridine 5'-phosphate
-
Methanothermobacter thermautotrophicus
0.0011
-
6-aza-uridine 5'-monophosphate
-
Plasmodium falciparum
0.002
-
6-azido-uridine 5'-monophosphate
-
Plasmodium falciparum
0.0021
-
6-amino-uridine 5'-monophosphate
-
Plasmodium falciparum
0.0124
-
6-azauridine 5'-phosphate
-
Methanothermobacter thermautotrophicus
0.026
-
6-cyano-uridine 5'-monophosphate
-
Plasmodium falciparum
0.029
-
6-cyanouridine 5'-phosphate
-
Methanothermobacter thermautotrophicus
0.0341
-
6-methyl-uridine 5'-monophosphate
-
Plasmodium falciparum
0.134
-
6-methyluridine 5'-phosphate
-
Methanothermobacter thermautotrophicus