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Literature summary for 4.1.1.23 extracted from

  • Shostak, K.; Jones, E.
    Orotidylate decarboxylase: insights into the catalytic mechanism from substrate specificity studies (1992), Biochemistry, 31, 12155-12161.
    View publication on PubMed
Search for more literature for 4.1.1.23

Inhibitors

Inhibitors Comment Organism Structure
5-Bromoorotidylate
-
 Saccharomyces cerevisiae
5-Chloroorotidylate
-
 Saccharomyces cerevisiae
6-azauridine 5'-phosphate
-
 Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0015
-
 orotidine 5'-phosphate
-
 Saccharomyces cerevisiae
0.02
-
 4-Thioorotidine 5'-phosphate
-
 Saccharomyces cerevisiae
0.03
-
 5-Azaorotidine 5'-phosphate
-
 Saccharomyces cerevisiae
0.056
-
 5-Fluoroorotidine 5'-phosphate
-
 Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc no zinc detected Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-Thioorotidine 5'-phosphate
-
 Saccharomyces cerevisiae 4-Thiouridine 5'-phosphate + CO2
-
 ?
5-Azaorotidine 5'-phosphate
-
 Saccharomyces cerevisiae 5-Azauridine 5'-phosphate + CO2
-
 ?
5-Fluoroorotidine 5'-phosphate
-
 Saccharomyces cerevisiae 5-Fluorouridine 5'-phosphate + CO2
-
 ?
Orotidine 5'-phosphate
-
 Saccharomyces cerevisiae UMP + CO2
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5
-
 5-Azaorotidine 5'-phosphate
-
 Saccharomyces cerevisiae
9
-
 4-Thioorotidine 5'-phosphate
-
 Saccharomyces cerevisiae
19
-
 orotidine 5'-phosphate
-
 Saccharomyces cerevisiae
570
-
 5-Fluoroorotidine 5'-phosphate
-
 Saccharomyces cerevisiae